Volume 40, Issue 1 pp. 122-129
Research Article

Comparison of Response Surface Methodology and Artificial Neural Network for Modeling Xylose-to-Xylitol Bioconversion

Fábio Coelho Sampaio

Fábio Coelho Sampaio

Department of Pharmacy, Federal University of Vales do Jequitinhonha e Mucuri, Campus JK, Rod. MGT 367, Km 583, n. 5000 – Alto da Jacuba, 39100-000 Diamantina, Minas Gerais, Brazil.

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Janaína Teles de Faria

Janaína Teles de Faria

Institute of Agricultural Sciences, Federal University of Minas Gerais, Av. Universitária, n. 1000 – Bairro Universitário, 39400-401 Montes Claros, Minas Gerais, Brazil.

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Gabriel Dumond de Lima Silva

Gabriel Dumond de Lima Silva

Department of Pharmacy, Federal University of Vales do Jequitinhonha e Mucuri, Campus JK, Rod. MGT 367, Km 583, n. 5000 – Alto da Jacuba, 39100-000 Diamantina, Minas Gerais, Brazil.

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Ricardo Melo Gonçalves

Ricardo Melo Gonçalves

Department of Pharmacy, Federal University of Vales do Jequitinhonha e Mucuri, Campus JK, Rod. MGT 367, Km 583, n. 5000 – Alto da Jacuba, 39100-000 Diamantina, Minas Gerais, Brazil.

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Cristiano Grijó Pitangui

Cristiano Grijó Pitangui

Department of Technology and Civil Engineering, Computation, Humanities, Federal University of São João Del-Rei, Campus Alto Paraopeba, Rod.: MG 443, Km 7, 36420-000, Ouro Branco, Minas Gerais, Brazil.

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Alessandro Alberto Casazza

Alessandro Alberto Casazza

Department of Civil, Chemical, and Environmental Engineering, University of Genoa, via Opera Pia 15, 16145 Genoa, Italy.

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Saleh Al Arni

Saleh Al Arni

Department of Chemical Engineering, Kind Saudi University, P.O. Box 800, Riyadh 11421, Saudi Arabia.

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Attilio Converti

Corresponding Author

Attilio Converti

Department of Civil, Chemical, and Environmental Engineering, University of Genoa, via Opera Pia 15, 16145 Genoa, Italy.

Department of Civil, Chemical, and Environmental Engineering, University of Genoa, via Opera Pia 15, 16145 Genoa, Italy.Search for more papers by this author
First published: 21 September 2016
Citations: 7

Abstract

Previous experimental data of xylose-to-xylitol bioconversion by Debaryomyces hansenii carried out according to a 33 full factorial design were used to model this process by two different artificial neural network (ANN) training methods. Models obtained for four responses were compared with those of response surface methodology (RSM). ANN models were shown to be superior to RSM in the predictive capacity, whereas the latter showed better performance in the generalization capability step. RSM with optimization using a genetic algorithm was revealed as a whole to be the best modeling option, which suggests that the comparative performances of RSM and ANN may be a highly problem-specific issue.

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