Intra-aortic balloon pump in cardiogenic shock: A propensity score matching analysis
Sheng Yuan MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Sheng Yuan and Jining He contributed equally to this study.
Search for more papers by this authorJining He MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Sheng Yuan and Jining He contributed equally to this study.
Search for more papers by this authorZhongxing Cai MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorRui Zhang MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorChenxi Song MD, PhD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorZheng Qiao MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorWeihua Song MD, PhD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiology, Coronary Heart Disease Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorLei Feng MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiology, Coronary Heart Disease Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorCorresponding Author
Kefei Dou MD, PhD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Correspondence Kefei Dou, MD, PhD, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167A Beilishi Rd, Xi Cheng, 100037 Beijing, China.
Email: [email protected]
Search for more papers by this authorSheng Yuan MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Sheng Yuan and Jining He contributed equally to this study.
Search for more papers by this authorJining He MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Sheng Yuan and Jining He contributed equally to this study.
Search for more papers by this authorZhongxing Cai MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorRui Zhang MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorChenxi Song MD, PhD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorZheng Qiao MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorWeihua Song MD, PhD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiology, Coronary Heart Disease Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorLei Feng MD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiology, Coronary Heart Disease Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Search for more papers by this authorCorresponding Author
Kefei Dou MD, PhD
State Key Laboratory of Cardiovascular Disease, Beijing, China
Department of Cardiometabolic Medicine, Cardiometabolic Medicine Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Correspondence Kefei Dou, MD, PhD, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167A Beilishi Rd, Xi Cheng, 100037 Beijing, China.
Email: [email protected]
Search for more papers by this authorAbstract
Objective
To assess the impact of intra-aortic balloon pumps (IABP) on patients with cardiogenic shock in an intensive care unit setting.
Background
IABP counterpulsation is a widely used mechanical circulatory support device, but its performance has been questioned. However, current evidence of IABP use in cardiogenic shock is very limited (mainly from the IABP-SHOCK II trial), which was restricted to cardiogenic shock complicating acute myocardial infarction.
Methods
This was a retrospective, real-world, cohort study based on the Medical Information Mart for Intensive Care III database. Adult patients with a diagnosis of cardiogenic shock were eligible.
Results
A total of 1028 patients with cardiogenic shock were assessed, including 384 patients who received IABP and 644 patients who did not. The in-hospital mortality was significantly lower in patients who received IABP (adjusted odds ratio: 0.75, 95% confidence interval: 0.62–0.91, p = 0.009). Analysis of secondary endpoints found that the use of IABP was associated with a significantly lower risk of 1-year mortality. After propensity score matching, the in-hospital mortality remained significantly lower in the IABP group (28.10% vs. 37.59%, p = 0.018).
Conclusions
In the current cohort, IABP treatment was associated with a lower risk of in-hospital mortality in patients with cardiogenic shock. Due to the complexity of pathophysiology in cardiogenic shock and the discrepancies in current evidence, our results should be validated through further studies in the future.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the MIMIC-III database (https://physionet.org/content/mimiciii/1.4/).
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