Volume 92, Issue 3 pp. 583-591
Valvular and Structural Heart Diseases

Infective endocarditis following transcatheter edge-to-edge mitral valve repair: A systematic review

Lluis Asmarats MD

Lluis Asmarats MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Tania Rodriguez-Gabella MD

Tania Rodriguez-Gabella MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Chekrallah Chamandi MD

Chekrallah Chamandi MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Mathieu Bernier MD

Mathieu Bernier MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Jonathan Beaudoin MD

Jonathan Beaudoin MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Kim O'Connor MD

Kim O'Connor MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Eric Dumont MD

Eric Dumont MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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François Dagenais MD

François Dagenais MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Jean-Michel Paradis MD

Jean-Michel Paradis MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

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Josep Rodés-Cabau MD

Corresponding Author

Josep Rodés-Cabau MD

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada

Correspondence Josep Rodés-Cabau, MD, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. Email: [email protected]Search for more papers by this author
First published: 10 May 2018
Citations: 30

Funding information: Drs. Asmarats and Rodriguez-Gabella are supported by a research grant from the Fundación Alfonso Martín Escudero (Spain). Dr. Rodés-Cabau holds the Canadian Research Chair “Fondation Famille Jacques Larivière” for the Development of Structural Heart Disease Interventions

Abstract

Objectives

To assess the clinical characteristics, management, and outcomes of patients diagnosed with infective endocarditis (IE) after edge-to-edge mitral valve repair with the MitraClip device.

Background

Transcatheter edge-to-edge mitral valve repair has emerged as an alternative to surgery in high-risk patients. However, few data exist on IE following transcatheter mitral procedures.

Methods

Four electronic databases (PubMed, Google Scholar, Embase, and Cochrane Library) were searched for original published studies on IE after edge-to-edge transcatheter mitral valve repair from 2003 to 2017.

Results

A total of 10 publications describing 12 patients with definitive IE (median age 76 years, 55% men) were found. The mean logistic EuroSCORE/EuroSCORE II were 41% and 45%, respectively. The IE episode occurred early (within 12 months post-procedure) in nine patients (75%; within the first month in five patients). Staphylococcus aureus was the most frequent (60%) causal microorganism, and severe mitral regurgitation was present in all cases but one. Surgical mitral valve replacement (SMVR) was performed in most (67%) patients, and the mortality associated with the IE episode was high (42%).

Conclusions

IE following transcatheter edge-to-edge mitral valve repair is a rare but life-threatening complication, usually necessitating SMVR despite the high-risk profile of the patients. These results highlight the importance of adequate preventive measures and a prompt diagnosis and treatment of this serious complication.

CONFLICT OF INTEREST

The authors do not report any conflict of interest with respect to the content of this article.

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