Volume 21, Issue 9 e202401273
Research Article

Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity

Prof. Dr. Phan Van Kiem

Corresponding Author

Prof. Dr. Phan Van Kiem

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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MSc. Nguyen Van Quoc

MSc. Nguyen Van Quoc

School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010 Vietnam

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Dr. Bui Huu Tai

Dr. Bui Huu Tai

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Dr. Pham Hai Yen

Dr. Pham Hai Yen

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Nguyen Huy Hoang

Nguyen Huy Hoang

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Dan Thi Thuy Hang

Dan Thi Thuy Hang

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Dr. Phan Thi Thanh Huong

Dr. Phan Thi Thanh Huong

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Ngo Anh Bang

Ngo Anh Bang

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Dr. Duong Thi Dung

Dr. Duong Thi Dung

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Dr. Do Thi Trang

Dr. Do Thi Trang

Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam

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Prof. Dr. Le Duc Giang

Prof. Dr. Le Duc Giang

Department of Chemistry, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010 Vietnam

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First published: 03 June 2024

Abstract

Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A–E (15), and three known ones (68) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1–8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 μM, compared to that of the positive control compound, dexamethazone (IC50 13.6 μM).

Graphical Abstract

Conflict of Interests

The authors declare no conflict of interest.

Data Availability Statement

The data that support the findings of this study are available in the supplementary material of this article.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.