Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity
Corresponding Author
Prof. Dr. Phan Van Kiem
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorMSc. Nguyen Van Quoc
School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010 Vietnam
Search for more papers by this authorDr. Bui Huu Tai
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Pham Hai Yen
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorNguyen Huy Hoang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDan Thi Thuy Hang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Phan Thi Thanh Huong
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorNgo Anh Bang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Duong Thi Dung
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Do Thi Trang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorProf. Dr. Le Duc Giang
Department of Chemistry, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010 Vietnam
Search for more papers by this authorCorresponding Author
Prof. Dr. Phan Van Kiem
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorMSc. Nguyen Van Quoc
School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010 Vietnam
Search for more papers by this authorDr. Bui Huu Tai
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Pham Hai Yen
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorNguyen Huy Hoang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDan Thi Thuy Hang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Phan Thi Thanh Huong
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorNgo Anh Bang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Duong Thi Dung
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorDr. Do Thi Trang
Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Search for more papers by this authorProf. Dr. Le Duc Giang
Department of Chemistry, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010 Vietnam
Search for more papers by this authorAbstract
Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A–E (1–5), and three known ones (6–8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1–8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 μM, compared to that of the positive control compound, dexamethazone (IC50 13.6 μM).
Graphical Abstract
Conflict of Interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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