The Sources, Structures and Cytotoxicity of Animal-Derived Bisindole Compounds
Zi-Long Zhang
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P.R. China
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorHao-Nan Xu
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorChuan-Ming Gong
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorDr. Yu-Ze Li
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorProf. Dr. Yi-Ming Li
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P.R. China
Search for more papers by this authorProf. Dr. Xiao-Mei Song
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorCorresponding Author
Prof. Dr. Rui Wang
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P.R. China
Search for more papers by this authorCorresponding Author
Prof. Dr. Dong-Dong Zhang
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorZi-Long Zhang
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P.R. China
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorHao-Nan Xu
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorChuan-Ming Gong
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorDr. Yu-Ze Li
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorProf. Dr. Yi-Ming Li
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P.R. China
Search for more papers by this authorProf. Dr. Xiao-Mei Song
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorCorresponding Author
Prof. Dr. Rui Wang
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P.R. China
Search for more papers by this authorCorresponding Author
Prof. Dr. Dong-Dong Zhang
School of Pharmacy, Shaanxi Key Laboratory of Research and Application of “Taibai Qi Yao”, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046 P.R. China
Search for more papers by this authorAbstract
Bisindole compounds constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the past four decades, researchers have isolated 229 animal-derived bisindole compounds (ADBCs) from various animals. These compounds demonstrate a wide range of pharmacological properties, including cytotoxicity, antibacterial, antifungal, antiviral, and other activities. Notably, among these activities, cytotoxicity emerges as the most prominent characteristic of ADBCs. This review also summarizes the structureactivity relationship (SAR) studies associated with the cytotoxicity of these compounds and explores the druggability of these compounds. In summary, our objective is to provide an overview of the research progress concerning ADBCs, with the aim of fostering their continued development and utilization.
Graphical Abstract
Conflict of Interests
The authors declare no conflict of interest.
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