Review
Progress in the Total Synthesis of Antitumor Tetrahydroisoquinoline Alkaloids
Yi Gao,
Ni Tu,
Xiaoting Liu,
Kangkang Lu,
Siyu Chen,
Ju Guo,
Yi Gao
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorNi Tu
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorXiaoting Liu
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorKangkang Lu
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorSiyu Chen
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorCorresponding Author
Ju Guo
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorYi Gao,
Ni Tu,
Xiaoting Liu,
Kangkang Lu,
Siyu Chen,
Ju Guo,
Yi Gao
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorNi Tu
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorXiaoting Liu
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorKangkang Lu
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorSiyu Chen
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorCorresponding Author
Ju Guo
Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205 China
Search for more papers by this authorAbstract
Among the tetrahydroisoquinoline(THIQ) of natural products, a family of THIQ alkaloids has the characteristics of similar biosynthetic pathway. Such THIQ alkaloids family mainly include Renieramycins, Ecteinasicdins, Tetrazaomine, Lemonomycin, etc. Most of these natural compounds have strong antitumor activities, and its family member Ecteinasicdins743 (ET-743, Trabectedin) has been marketed in the European Union and the United States for the treatment of advanced soft tissue tumors and ovarian cancer. Because of the excellent biological activity and complex chemical structure of this kind of THIQ products, it has aroused great interest of biologists and chemists, and many synthetic chemists have paid considerable efforts to their total synthesis over the past decade. Based on this, the recent advances in the total synthesis of such THIQ alkaloids are reviewed.
Graphical Abstract
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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