Antidepressant-Like Effect and Phenolic Profile of Brazilian Native and Exotic Species from Psidium Genus
Natalia Cavichioli
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorAna Paula Dalmagro
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorOtto Rodolfo Sasse
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorLucas Henrique Junges
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorAndrey Martinez Rebelo
Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina, EPAGRI, CEP 88318-112 Itajaí, Santa Catarina, Brazil
Search for more papers by this authorCássia Katrin Reinke
Serviço Nacional de Aprendizagem Industrial, SENAI, Instituto SENAI de Tecnologia Ambiental, CEP 89637-050 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorCorresponding Author
Ana Lúcia Bertarello Zeni
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Programa de Pós-Graduação em Biodiversidade, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorNatalia Cavichioli
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorAna Paula Dalmagro
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorOtto Rodolfo Sasse
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorLucas Henrique Junges
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorAndrey Martinez Rebelo
Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina, EPAGRI, CEP 88318-112 Itajaí, Santa Catarina, Brazil
Search for more papers by this authorCássia Katrin Reinke
Serviço Nacional de Aprendizagem Industrial, SENAI, Instituto SENAI de Tecnologia Ambiental, CEP 89637-050 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorCorresponding Author
Ana Lúcia Bertarello Zeni
Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Programa de Pós-Graduação em Biodiversidade, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil
Search for more papers by this authorAbstract
Depression is one of the disorders involving mental health that most affects the population worldwide. Considering the available pharmacological therapies for the treatment of depression are ineffective in most patients, the search for new alternatives is crucial. In line with this, we investigated the phenolic profile, antidepressant-like, and antioxidant effects triggered by the administration of aqueous extracts from Psidium guajava L. (GUA), Psidium cattleianum Sw. (CAT), and Psidium guineense Sabine (GUI) leaves in mice. Our results show that quercetin is the major compound of GUA and GUI, and o-coumaric acid in CAT extracts. The acute and subchronic administrations of the three plant extracts exerted an antidepressant-like effect in mice exposed to the tail suspension test, without changes on locomotor performance evaluated by the open field test. Furthermore, the GUI and CAT decreased oxidative stress markers, mainly lipid peroxidation and nitrites in the hippocampus, prefrontal cortex, liver, and plasma. Notably, GUA and CAT increased non-protein thiols in all tissues. Therefore, the Psidium extracts demonstrated an antidepressant-like effect in mice, and the antioxidant capacity of the extracts seems to underlie the behavioral effect.
Graphical Abstract
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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