New Bioactive Sulfated Alkenes from the Sea Cucumber Apostichopus japonicus
Ming-Ping La
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorCui Li
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorLing Li
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorPeng Sun
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorHua Tang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorBao-Shu Liu
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorWei Gong
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorHua Han
College of Animal Sciences, Zhejiang University, 268 Kai-Xuan Road, Hangzhou 310029, P. R. China
Search for more papers by this authorCorresponding Author
Yang-Hua Yi
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)Search for more papers by this authorCorresponding Author
Wen Zhang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)Search for more papers by this authorMing-Ping La
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorCui Li
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorLing Li
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorPeng Sun
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorHua Tang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorBao-Shu Liu
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorWei Gong
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Search for more papers by this authorHua Han
College of Animal Sciences, Zhejiang University, 268 Kai-Xuan Road, Hangzhou 310029, P. R. China
Search for more papers by this authorCorresponding Author
Yang-Hua Yi
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)Search for more papers by this authorCorresponding Author
Wen Zhang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China (phone/fax: +86-21-81871257)Search for more papers by this authorAbstract
Two new alkene sulfates, (5Z)-dec-5-en-1-yl sulfate (4) and (3E)-dec-3-en-1-yl sulfate (5), together with three known sulfated alkanes, 2,6-dimethylheptyl sulfate (1), octyl sulfate (2), and decyl sulfate (3), were isolated from the sea cucumber Apostichopus japonicus. The structures of the new compounds 4 and 5 were elucidated by spectroscopic analysis, including 1H-, 13C-, and 2D-NMR, ESI-MS, and HR-ESI-MS. Compounds 2 and 3 were isolated from natural sources for the first time. In preliminary bioassays in vitro, compounds 4 and 5 showed antibacterial, antifungal, and cytotoxic activities.
Graphical Abstract
References
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