Medicinal Studies of Dimeric Phenols with Multiple Quaternary-Ammonium Pendant Arms
Tian Tian
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
T. T. and X.-C. W. contributed equally to this work.
Search for more papers by this authorXiao-Cheng Weng
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Search for more papers by this authorYang Song
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Search for more papers by this authorLi-Xia Zhang
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Search for more papers by this authorXiang Zhou
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Ministry of Education, Key Laboratory of Biomedicine, Wuhan University, Hubei, Wuhan 430072, P. R. China
State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430071, P. R. China
Search for more papers by this authorYi Wang
State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430071, P. R. China
Search for more papers by this authorTian Tian
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
T. T. and X.-C. W. contributed equally to this work.
Search for more papers by this authorXiao-Cheng Weng
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Search for more papers by this authorYang Song
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Search for more papers by this authorLi-Xia Zhang
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Search for more papers by this authorXiang Zhou
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China, (phone: +86-27-61056559; fax: +86-27-87336380)
Ministry of Education, Key Laboratory of Biomedicine, Wuhan University, Hubei, Wuhan 430072, P. R. China
State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430071, P. R. China
Search for more papers by this authorYi Wang
State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430071, P. R. China
Search for more papers by this authorAbstract
A series of biphenol-derived quaternary ammonium salts, originally developed as DNA-cross-linking agents, and carrying either two (i.e., 1) or four (i.e., 2) net positive charges, were investigated for their in vitro DNA-transcription- and acetylcholinesterase (AChE)-inhibitory activities. The effects of charge and type of linker between the two phenolic residues were systematically investigated. Several compounds showed good activities in both tests, which makes them potential lead candidates for drug design.
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