Two New Protease-Inhibiting Glycosphingolipids from Buddleja crispa
Ijaz Ahmad
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorItrat Anis
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorItrat Fatima
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorAbdul Malik
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorShafiullah Khan
Pharmaceutical Research Centre, PCSIR, Laboratories Complex Karachi, Karachi-75280, Pakistan
Search for more papers by this authorNighat Afza
Pharmaceutical Research Centre, PCSIR, Laboratories Complex Karachi, Karachi-75280, Pakistan
Search for more papers by this authorRasool Bakhsh Tareen
Department of Botany, Baluchistan University, Saryab Road, Quetta, Pakistan
Search for more papers by this authorMuhammad Arif Lodhi
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorM. Iqbal Choudhary
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorIjaz Ahmad
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorItrat Anis
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorItrat Fatima
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorAbdul Malik
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorShafiullah Khan
Pharmaceutical Research Centre, PCSIR, Laboratories Complex Karachi, Karachi-75280, Pakistan
Search for more papers by this authorNighat Afza
Pharmaceutical Research Centre, PCSIR, Laboratories Complex Karachi, Karachi-75280, Pakistan
Search for more papers by this authorRasool Bakhsh Tareen
Department of Botany, Baluchistan University, Saryab Road, Quetta, Pakistan
Search for more papers by this authorMuhammad Arif Lodhi
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorM. Iqbal Choudhary
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, (phone: +92-21-4824926)
Search for more papers by this authorAbstract
Crispins A (1) and B (2), two new glycosphingolipids, were isolated from the whole plant Buddleja crispa, along with three known compounds: α-amyrin, linoleic acid, and stigmasterol. Their structures were elucidated by chemical and spectroscopic techniques. Both 1 and 2 showed significant inhibitory activity against α-chymotrypsin in a concentration-dependent manner.
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