Synthesis and Cytotoxic Evaluation of Substituted Urea Derivatives as Inhibitors of Human-Leukemia K562 Cells
Ping Cao
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorXian-Feng Huang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHui Ding
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHui-Ming Ge
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHuan-Qiu Li
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorBan-Feng Ruan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHai-Liang Zhu
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorPing Cao
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorXian-Feng Huang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHui Ding
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHui-Ming Ge
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHuan-Qiu Li
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorBan-Feng Ruan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorHai-Liang Zhu
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone and fax: +86-25-8359 2672)
Search for more papers by this authorAbstract
A series of substituted urea derivatives, compounds 1–14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line. Two structurally simple compounds, 7 and 12, both incorporating a morpholine ring, were found to be highly active, with IC50 values of ca. 0.25 μM.
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