This study aims to establish and analyze the significant barriers to adopting Circular Supply Chain Management (CSCM) in Indian Micro, Small, and Medium Enterprises (MSMEs). The research employs novel mixed-method approaches in its pursuit. A literature review and expert opinions assist in identifying the significant barriers. A quantitative combinational DANP methodology, integrating a Decision-Making Trial and Evaluation Laboratory (DEMATEL) with the Analytic Network Process (ANP), is utilized to analyze causal relationships and interrelations and to ultimately rank the critical barriers. The study reveals that economic and technological challenges are the most prominent causal factors, exacerbating regulatory and social issues, particularly in India's MSME sector. The findings have broad implications for industry experts, policymakers, and researchers in formulating successful interventions that promote circular adoption in MSMEs. This study contributes to the existing literature on CSCM and MSMEs by presenting challenges in emerging markets, specifically considering India's unique economic and regulatory environment.