Dogger bank itch. 2. An allergic contact dermatitis

Jørgen S. Carlé

Marine Chemistry Section, Department of General and Organic Chemistry, The H. C. Ørsted Institute, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark

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Carsten Christophersen,

Carsten Christophersen

Marine Chemistry Section, Department of General and Organic Chemistry, The H. C. Ørsted Institute, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark

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Jørgen S. Carlé,

Jørgen S. Carlé

Marine Chemistry Section, Department of General and Organic Chemistry, The H. C. Ørsted Institute, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark

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Carsten Christophersen,

Carsten Christophersen

Marine Chemistry Section, Department of General and Organic Chemistry, The H. C. Ørsted Institute, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark

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First published: 1980

https://doi.org/10.1002/bscb.19800891210

Citations: 10

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Abstract

Dogger Bank Itch is an allergic contact dermatitis representing a severe occupational hazard among trawlermen of the Dogger Bank Area in the North Sea. Allergic sensitivity is acquired following exposure to the marine bryozoan Alcyonidium gelatinosum. The allergen has been identified as (2-hydroxyethyl) dimethylsulfoxonium ion. The isolation, structure determination and synthesis of the allergen is discussed.

References

(1) (a) P. Bonnevie, Acta Allerg. (Kbh.), 1 40 (1948);
10.1111/j.1398-9995.1948.tb03301.x
CAS PubMed Google Scholar
(b) M. L. Newhouse, Brit. med. J., 1, 1142 (1966);
10.1136/bmj.1.5496.1142
CAS PubMed Web of Science® Google Scholar
(c) A. Guldager, Ugeskr, læg., 41, 1567 (1959);
Google Scholar
(d) B. W. Halstead, “Poisonous and Venomous Marine Animals of the World”, Revised Edition, The Darwin Press, Inc., Princeton, New Jersey, 1978, pp. 289–291.
Google Scholar
(2) C. Audebert and P. Lamoureux, Ann. Dermatol. Venereol. (Paris), 105, 187 (1978).
CAS PubMed Web of Science® Google Scholar
(3) The genus Alcyonidium is taxonomically very complex and is evidently in need of extensive revision. J. P. Thorpe, J. A. Beardmore and J. S. Ryland, Mar. Biol., 49, 27 (1978).
10.1007/BF00390727
Web of Science® Google Scholar
(4) Alcyonidium hirsutum Flemming: lb; Fragilaria striatula Lyngb.: J. H. Fraser and A. Lyell, The Lancet, 61 (1963);
Google Scholar
Y. Hashimoto, “Marine Toxins and Other Bioactive Marine Metabolites”, Japan Scientific Societies Press, Tokyo, 1979, p. 230;
Web of Science® Google Scholar
(5) A. N. Domonkos, “Andrews' Diseases of the Skin, Clinical Dermatology”, W. B. Saunders Company, 1971, p. 95.
Google Scholar
(6) P. Bonnevie, Acta Dermatoven. 20, 645 (1939).
Google Scholar
(7) S. Patkar Dr.. Personal communication.
Google Scholar
(8) R. H. Seville, Brit. J. Derm., 69, 92 (1957).
10.1111/j.1365-2133.1957.tb13235.x
CAS PubMed Web of Science® Google Scholar
(9) M. L. Newhouse, Brit. Med. J., 1, 1142 (1966).
10.1136/bmj.1.5496.1142
CAS PubMed Web of Science® Google Scholar
(10) L. Vanggaard, Ugeskr. Læg., 7, 413 (1977).
Google Scholar
(11) A detailled account of the medical aspects concerning this work is in preparation. CarléJ. S., C. Christophersen and H. Thybo, to be published.
Google Scholar
(12) All NMR data were obtained from D2O solutions containing various amounts of salts. DSS was used as external standard.
Google Scholar
(13) F. W. McLafferty, Accounts Chem. Res., 13, 33 (1980).
10.1021/ar50146a001
CAS Web of Science® Google Scholar
(14) A detained account and discussion of all the spectrospic data leading to the structure are given in J. S. Carlé, C. Christophersen, J. Amer. Chem. Soc., 102, 5107 (1980).
10.1021/ja00535a053
CAS Web of Science® Google Scholar
(15) The synthesis is by no means trivial, and is to be reported elsewhere.
Google Scholar

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Volume89, Issue12

1980

Pages 1087-1091

Dogger bank itch. 2. An allergic contact dermatitis

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Dogger bank itch. 2. An allergic contact dermatitis

Abstract

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