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Molecular mechanisms involved in Ras inactivation: the annexin A6–p120GAP complex
Thomas Grewal,
Carlos Enrich,
Corresponding Author
Thomas Grewal
Centre for Immunology, St. Vincent's Hospital, University of New South Wales, Sydney, Australia.
Centre for Immunology, St. Vincent's Hospital, Darlinghurst NSW 2010, Sydney, Australia.Search for more papers by this authorCarlos Enrich
Departament de Biologia Celluar, Institut d'Investigacions de Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
Search for more papers by this authorThomas Grewal,
Carlos Enrich,
Corresponding Author
Thomas Grewal
Centre for Immunology, St. Vincent's Hospital, University of New South Wales, Sydney, Australia.
Centre for Immunology, St. Vincent's Hospital, Darlinghurst NSW 2010, Sydney, Australia.Search for more papers by this authorCarlos Enrich
Departament de Biologia Celluar, Institut d'Investigacions de Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
Search for more papers by this authorAbstract
In mammalian cells, a complex network of signaling pathways tightly regulates a variety of cellular processes, such as proliferation and differentiation. New insights from one of the most-important signaling cascades involved in oncogenesis, the Ras–Raf–MAPK pathway, suggest that the subcellular localisation and assembly of signaling modules of this pathway is crucial to control the biological response. This commonly requires membrane targeting events that are mediated by adaptor/scaffold proteins. Of particular interest is the translocation and complex formation of GTPase-activating proteins (GAPs), such as p120GAP, at the plasma membrane to inactivate Ras. Recent studies indicate that one member of the annexin family, annexin A6 acts as a targeting protein for p120GAP. This review discusses how annexin A6 modulates the involvement of negative regulators of the Ras–Raf–MAPK pathway contributing to Ras inactivation. BioEssays 28: 1211–1220, 2006. © 2006 Wiley Periodicals, Inc.
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