Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder
Corresponding Author
Şeref Şimşek
Department of Child Psychiatry, Dicle University, Medical School, Diyarbakır, Turkey
Address for correspondence and reprints: Şeref Şimşek, Dicle University Medical School, Department of Child Psychiatry, Diyarbakır, Turkey. E-mail: [email protected]Search for more papers by this authorİhsan Çetin
Department of Nutrition and Dietetics, Batman University, School of Health Sciences, Batman, Turkey
Search for more papers by this authorAbdullah Çim
Department of Medical Genetics, Dicle University, Medical School, Diyarbakır, Turkey
Search for more papers by this authorSavaş Kaya
Department of Immunology, Dicle University, Medical School, Diyarbakır, Turkey
Search for more papers by this authorCorresponding Author
Şeref Şimşek
Department of Child Psychiatry, Dicle University, Medical School, Diyarbakır, Turkey
Address for correspondence and reprints: Şeref Şimşek, Dicle University Medical School, Department of Child Psychiatry, Diyarbakır, Turkey. E-mail: [email protected]Search for more papers by this authorİhsan Çetin
Department of Nutrition and Dietetics, Batman University, School of Health Sciences, Batman, Turkey
Search for more papers by this authorAbdullah Çim
Department of Medical Genetics, Dicle University, Medical School, Diyarbakır, Turkey
Search for more papers by this authorSavaş Kaya
Department of Immunology, Dicle University, Medical School, Diyarbakır, Turkey
Search for more papers by this authorAbstract
Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P = 0.025) and E-selectin (P = 0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r = −0.349, P = 0.04; r = −0.411, P = 0.01; r = −0.412, P = 0.01; r = −0.417, P = 0.01, and r = −0.531, P < 0.01, respectively). Serum levels of P-selectin levels showed statistically significant negative correlation with ABC total score in the patient group (r = −0.378, P = 0.03). It may be suggested that t-PA, E-selectin, P-selectin, and sPECAM-1 a crucial role in inflammatory conditions in children with ASD. Autism Res 2016, 9: 1241–1247. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
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Figure S1: There was no significant difference between patient group and controls in terms of t-PA and E-Selectin levels in females. |
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