Concise Communication
Regulation of the symmetry and intensity of immune complex–mediated synovitis by nuclear factor of activated T cells
Andrea J. Gerth BS,
Christine T. N. Pham MD,
Stanford L. Peng MD, PhD,
Andrea J. Gerth BS
Washington University School of Medicine, St. Louis, MO
Search for more papers by this authorChristine T. N. Pham MD
Washington University School of Medicine, St. Louis, MO
Search for more papers by this authorStanford L. Peng MD, PhD
Washington University School of Medicine, St. Louis, MO
Search for more papers by this authorAndrea J. Gerth BS,
Christine T. N. Pham MD,
Stanford L. Peng MD, PhD,
Andrea J. Gerth BS
Washington University School of Medicine, St. Louis, MO
Search for more papers by this authorChristine T. N. Pham MD
Washington University School of Medicine, St. Louis, MO
Search for more papers by this authorStanford L. Peng MD, PhD
Washington University School of Medicine, St. Louis, MO
Search for more papers by this author
References
- 1 Sergent JS. Polyarticular arthritis. In: S Ruddy, ED Harris, CB Sledge, editors. Kelley's Textbook of Rheumatology. 6th ed. Philadelphia: WB Saunders; 2001. p. 379–85.
- 2 Harris ED Jr. Clinical features of rheumatoid arthritis. In: S Ruddy, ED Harris, CB Sledge, editors. Kelley's Textbook of Rheumatology. 6th ed. Philadelphia: WB Saunders; 2001. p. 967–1000.
- 3 Gladman DD, Rahman P. Psoriatic arthritis. In: S Ruddy, ED Harris, CB Sledge, editors. Kelley's Textbook of Rheumatology. 6th ed. Philadelphia: WB Saunders; 2001. p. 1071–9.
- 4 Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997; 15: 707–47.
- 5 Cranney A, Tugwell P. The use of Neoral in rheumatoid arthritis. Rheum Dis Clin North Am 1998; 24: 479–88.
- 6 Ivery MT. Immunophilins: switched on protein binding domains? Med Res Rev 2000; 20: 452–84.
- 7 Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med 2001; 344: 655–64.
- 8 Aramburu J, Rao A, Klee CB. Calcineurin: from structure to function. Curr Top Cell Regul 2000; 36: 237–95.
- 9 Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, Glimcher LH. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 1996; 4: 397–405.
- 10 Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D. Organ-specific disease provoked by systemic autoimmunity. Cell 1996; 87: 811–22.
- 11 Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J, et al. Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med 2002; 195: 1071–7.
- 12 Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, et al. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 2002; 3: 360–5.
- 13 Wipke BT, Allen PM. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 2001; 167: 1601–8.
- 14 Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. [see comment] Science 2002; 297: 1689–92.
- 15 Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, et al. Arthritis critically dependent on innate immune system players. Immunity 2002; 16: 157–68.
- 16 Xu L, Zhang L, Yi Y, Kang HK, Datta SK. Human lupus T cells resist inactivation and escape death by upregulating COX-2. Nat Med. In press and available online, URL: doi: 10.1038/nm1005.
- 17 Zhang HG, Hyde K, Page GP, Brand JP, Zhou J, Yu S, et al. Novel tumor necrosis factor α–regulated genes in rheumatoid arthritis. Arthritis Rheum. 2004; 50: 420–31.
- 18 Ranger AM, Oukka M, Rengarajan J, Glimcher LH. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 1998; 9: 627–35.
- 19 Allen ME, Young SP, Michell RH, Bacon PA. Altered T lymphocyte signaling in rheumatoid arthritis. Eur J Immunol 1995; 25: 1547–54.
- 20 Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 2002; 3: 889–901.
- 21 Sherman MA, Powell DR, Weiss DL, Brown MA. NF-ATc isoforms are differentially expressed and regulated in murine T and mast cells. J Immunol 1999; 162: 2820–8.
- 22 Viola JP, Kiani A, Bozza PT, Rao A. Regulation of allergic inflammation and eosinophil recruitment in mice lacking the transcription factor NFAT1: role of interleukin-4 (IL-4) and IL-5. Blood 1998; 91: 2223–30.
- 23 Gerth AJ, Lin L, Neurath MF, Glimcher LH, Peng SL. An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells. Gastroenterology 2004; 126: 1115–21.
- 24 Matsumoto I, Staub A, Benoist C, Mathis D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 1999; 286: 1732–5.
- 25 Schramm C, Kriegsmann J, Protschka M, Huber S, Hansen T, Schmitt E, et al. Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells. Arthritis Res Ther 2004; 6: R114–9.