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Chemistry of Indoles Carrying a Basic Function, Part 31 Synthesis of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones with Antihypoxic Effects
Abstract
Hydroxyindolones (1–6, 15–16) were transformed into isatinylidenes (7,9–13, 17–19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21–32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.
