In Situ Synthesis of CNT-Bridged UiO-66-(COOH)2 on Polytetrafluoroethylene Porous Membrane for Portable Hemodialysis
Shuaiyang Jiang
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Writing - original draft (lead), Writing - review & editing (lead)
Search for more papers by this authorYa Liu
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Writing - original draft (lead), Writing - review & editing (lead)
Search for more papers by this authorYulu Liu
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Conceptualization (lead), Data curation (lead)
Search for more papers by this authorCorresponding Author
Dongfang Wang
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Correspondence:
Dongfang Wang ([email protected])
Xiaofeng Wang ([email protected])
Contribution: Project administration (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Xiaofeng Wang
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Correspondence:
Dongfang Wang ([email protected])
Xiaofeng Wang ([email protected])
Contribution: Project administration (lead), Resources (lead)
Search for more papers by this authorQian Li
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Project administration (lead), Resources (lead)
Search for more papers by this authorShuaiyang Jiang
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Writing - original draft (lead), Writing - review & editing (lead)
Search for more papers by this authorYa Liu
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Writing - original draft (lead), Writing - review & editing (lead)
Search for more papers by this authorYulu Liu
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Conceptualization (lead), Data curation (lead)
Search for more papers by this authorCorresponding Author
Dongfang Wang
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Correspondence:
Dongfang Wang ([email protected])
Xiaofeng Wang ([email protected])
Contribution: Project administration (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Xiaofeng Wang
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Correspondence:
Dongfang Wang ([email protected])
Xiaofeng Wang ([email protected])
Contribution: Project administration (lead), Resources (lead)
Search for more papers by this authorQian Li
School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, P. R. China
National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, P. R. China
Contribution: Project administration (lead), Resources (lead)
Search for more papers by this authorFunding: This work was supported by International Science & Technology Cooperation Program of China, 2015DFA30550 and Key scientific research project plan of colleges and universities in Henan Province, 24A130003.
Shuaiyang Jiang and Ya Liu contributed equally to this work.
ABSTRACT
A portable home hemodialysis device is a miniaturized and easy-to-operate medical apparatus designed for patients with chronic kidney disease, enabling them to conveniently perform hemodialysis at home or while traveling. However, it imposes high requirements on the dialysis membrane in terms of dialysis efficiency, adsorption capacity, and blood compatibility. In this study, the composite membrane was fabricated through electrospinning, which is an in situ synthesis of carbon nano tube (CNT)bridged UiO66(COOH)2 on PTFE fibers. UiO66(COOH)2 increased the adsorption site by association with CNT, and achieved the adsorption of creatinine by hydrogen bond and π bond, which greatly reduced the usage of dialysis solution. UiO66(COOH)2 and CNT were first combined for creatinine adsorption, and its maximum static adsorption capacity was 66 mg/g. During the dialysis, the yielding membrane showed a creatinine clearance of 64.89% and a resistance protein rate of more than 98%. Compared with pure PTFE dialysis membrane, the amount of dialysate used to achieve the same dialysis effect was merely 1/10. Furthermore, the membrane has a hemolysis rate of 2% and a low platelet adhesion rate, which shows excellent blood compatibility. Therefore, the dialysis membrane prepared in this study is expected to promote the development of portable home hemodialysis devices.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
All data supporting the findings of this study are available within the article and its Supporting Information files. They are also available from the corresponding authors upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| app56696-sup-0001-supinfo.docxWord 2007 document , 2.3 MB |
Data S1 Supporting Information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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