Human-lymphocyte cell friendly starch–hydroxyapatite biodegradable composites: Hydrophilic mechanism, mechanical, and structural impact
Corresponding Author
Sumit Pramanik
Composite Laboratory, Department of Mechanical Engineering, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Correspondence to: S. Pramanik (E-mail: [email protected] or [email protected])Search for more papers by this authorPratibha Agarwala
Composite Laboratory, Department of Mechanical Engineering, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Department of Medicinal Chemistry, Central University of Punjab, Punjab, India
Search for more papers by this authorKharthik Vasudevan
Composite Laboratory, Department of Mechanical Engineering, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Search for more papers by this authorKoustav Sarkar
SRM Research Institute and Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Search for more papers by this authorCorresponding Author
Sumit Pramanik
Composite Laboratory, Department of Mechanical Engineering, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Correspondence to: S. Pramanik (E-mail: [email protected] or [email protected])Search for more papers by this authorPratibha Agarwala
Composite Laboratory, Department of Mechanical Engineering, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Department of Medicinal Chemistry, Central University of Punjab, Punjab, India
Search for more papers by this authorKharthik Vasudevan
Composite Laboratory, Department of Mechanical Engineering, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Search for more papers by this authorKoustav Sarkar
SRM Research Institute and Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram 603203 Chennai, Tamil Nadu, India
Search for more papers by this authorABSTRACT
Biodegradable starch (Str) polymer was derived from potato, a plant-based natural carbohydrate polymers source, by one-pot synthesis. Hydroxyapatite (HA) was produced from goat bone by step sintering. The inexpensive starch/HA thin film composites were fabricated by customized spin coating. This study revealed that the hydrogen bond energy and distance have significant effect on glass transition temperature of the polymer. The 40 wt % HA contained starch (StrHA40) composite thin film showed excellent tensile strength (3.03 + −0.03 MPa), elongation (21.5 + −5.5%) and modulus (15.5 + −0.2 MPa) closed to human skin. The in vitro swelling and biodegradation kinetics of pristine starch and pure HA has been controlled and improved by using suitable composition. This study postulated the probable water molecule-adsorption mechanisms of pristine starch and starch/HA composite films. The StrHA40 composite showed excellent biocompatibility to the human-blood derived lymphocyte cells. Therefore, the starch/HA thin film composite-based biodegradable scaffolds developed in the present study can be an excellent potential candidate for soft tissue regeneration and/or replacement applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48913.
CONFLICT OF INTEREST
The authors declare no potential conflict of interest.
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