Volume 89, Issue 8 pp. 2277-2282

Chemically treated hard gelatin capsules for colon-targeted drug delivery: A novel approach

S. K. Bajpai

Corresponding Author

S. K. Bajpai

Department of Chemistry, Govt. of Autonomous Science College, Jabalpur (M.P.), India

Department of Chemistry, Govt. of Autonomous Science College, Jabalpur (M.P.), India===Search for more papers by this author
M. Bajpai

M. Bajpai

Department of Chemistry, Govt. of Autonomous Science College, Jabalpur (M.P.), India

Search for more papers by this author
R. Dengre

R. Dengre

All India Institute of Medical Sciences, New Delhi, India

Search for more papers by this author
First published: 11 June 2003
Citations: 26

Abstract

Hard gelatin capsules, containing riboflavin-loaded poly (N-viny1–2-pyrrolidone)-polyacrylamide cylindrical hydrogels, were modified chemically by treating with an aqueous formaldehyde solution for the purpose of delayed release of drug along the gastrointestinal tract. The tdis (disintegration time) of capsules was studied as a function of concentration of formaldehyde solution and the treatment time. The dynamic release of vitamin B2 was studied as a function of crosslinking ratio of the hydrogels. The device studied seems to have potential to be used for colon-targeted drug delivery. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2277–2282, 2003

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.