Click Chemistry: The Certainty of Chance (Nobel Lecture)**
Corresponding Author
K. Barry Sharpless
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA
Search for more papers by this authorM. G. Finn
School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, 30306 901 Atlantic Dr., USA
Nobel Laureate K. Barry Sharpless is joined by his click chemistry co-founders, M.G. Finn and Hartmuth C. Kolb who have collaborated with him in this journey, which includes this manuscript.
Contribution: Writing - review & editing (equal)
Search for more papers by this authorHartmuth C. Kolb
Enigma Biomedical Group, 308 N. Peters Road, Knoxville, 37922 USA
University of Wisconsin, Madison, 1111 Highland Ave #1005, Madison, WI 53705
Nobel Laureate K. Barry Sharpless is joined by his click chemistry co-founders, M.G. Finn and Hartmuth C. Kolb who have collaborated with him in this journey, which includes this manuscript.
Contribution: Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
K. Barry Sharpless
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA
Search for more papers by this authorM. G. Finn
School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, 30306 901 Atlantic Dr., USA
Nobel Laureate K. Barry Sharpless is joined by his click chemistry co-founders, M.G. Finn and Hartmuth C. Kolb who have collaborated with him in this journey, which includes this manuscript.
Contribution: Writing - review & editing (equal)
Search for more papers by this authorHartmuth C. Kolb
Enigma Biomedical Group, 308 N. Peters Road, Knoxville, 37922 USA
University of Wisconsin, Madison, 1111 Highland Ave #1005, Madison, WI 53705
Nobel Laureate K. Barry Sharpless is joined by his click chemistry co-founders, M.G. Finn and Hartmuth C. Kolb who have collaborated with him in this journey, which includes this manuscript.
Contribution: Writing - review & editing (equal)
Search for more papers by this authorPublished with permission of the Nobel Foundation.
Graphical Abstract
The click chemist's playground: The most important certainty-of-chance outcome of click chemistry was the realization that perfect reactions can exist. Chemistry is about bond-making and bond-breaking reactions between atoms and molecules. So, the emergence of “perfect reaction” status promises to be transformative to the very heart of chemistry, and thence to the range of benefits for mankind that its future evolution may hold.
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