Tensile Strain-Mediated Bimetallene Nanozyme for Enhanced Photothermal Tumor Catalytic Therapy
Dr. Jiandong Wu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Qihui Liu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Dongxu Jiao
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Bin Tian
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Qiong Wu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Xin Chang
Department of Breast Surgery, Second Hospital of Jilin University, No.4026 Yatai Street, Changchun, 130041 China
Search for more papers by this authorDr. Hongyu Chu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorShan Jiang
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Qi Yang
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Tao Liu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Yue Zhang
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorWei Zhang
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
Search for more papers by this authorDr. Jinchang Fan
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
Search for more papers by this authorCorresponding Author
Prof. Xiaoqiang Cui
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
Search for more papers by this authorCorresponding Author
Prof. Fangfang Chen
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Jiandong Wu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Qihui Liu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Dongxu Jiao
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Bin Tian
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Qiong Wu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Xin Chang
Department of Breast Surgery, Second Hospital of Jilin University, No.4026 Yatai Street, Changchun, 130041 China
Search for more papers by this authorDr. Hongyu Chu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorShan Jiang
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Qi Yang
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Tao Liu
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorDr. Yue Zhang
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorWei Zhang
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
Search for more papers by this authorDr. Jinchang Fan
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
Search for more papers by this authorCorresponding Author
Prof. Xiaoqiang Cui
State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130012 China
Search for more papers by this authorCorresponding Author
Prof. Fangfang Chen
Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, Electron Microscopy Center, China-Japan Union Hospital of Jilin University, No.126 Sendai Street, Changchun, 130033 China
Search for more papers by this authorGraphical Abstract
We present the first report on a novel tensile strain-mediated local amorphous RhRu (la-RhRu) bimetallene with exceptional intrinsic photothermal effect and photo-enhanced multiple enzyme-like activities. Functioning as a tumor microenvironment (TME)-responsive nanozyme, la-RhRu exhibits remarkable therapeutic efficacy both in vitro and in vivo. This work highlights the tremendous potential of atomic-scale tensile strain engineering strategy in enhancing tumor catalytic therapy.
Abstract
Nanozymes have demonstrated significant potential in combating malignant tumor proliferation through catalytic therapy. However, the therapeutic effect is often limited by insufficient catalytic performance. In this study, we propose the utilization of strain engineering in metallenes to fully expose the active regions due to their ultrathin nature. Here, we present the first report on a novel tensile strain-mediated local amorphous RhRu (la-RhRu) bimetallene with exceptional intrinsic photothermal effect and photo-enhanced multiple enzyme-like activities. Through geometric phase analysis, electron diffraction profile, and X-ray diffraction, it is revealed that crystalline-amorphous heterophase boundaries can generate approximately 2 % tensile strain in the bimetallene. The ultrathin structure and in-plane strain of the bimetallene induce an amplified strain effect. Both experimental and theoretical evidence support the notion that tensile strain promotes multiple enzyme-like activities. Functioning as a tumor microenvironment (TME)-responsive nanozyme, la-RhRu exhibits remarkable therapeutic efficacy both in vitro and in vivo. This work highlights the tremendous potential of atomic-scale tensile strain engineering strategy in enhancing tumor catalytic therapy.
Conflict of interests
The authors declare no competing financial interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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