π–π Interaction-Induced Organic Long-wavelength Room-Temperature Phosphorescence for In Vivo Atherosclerotic Plaque Imaging
Yufan Zhang
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
These authors contributed equally to this work.
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (lead), Writing - original draft (lead)
Search for more papers by this authorJisen Li
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
These authors contributed equally to this work.
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal)
Search for more papers by this authorJiliang Zhao
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Investigation (equal), Methodology (equal)
Search for more papers by this authorXuefei Li
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Investigation (equal), Methodology (equal)
Search for more papers by this authorZhimei Wang
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Conceptualization (supporting), Software (equal)
Search for more papers by this authorYicheng Huang
School of Chemistry and Materials Engineering, Wenzhou University, 325035 Wenzhou, China
Contribution: Investigation (supporting), Methodology (supporting)
Search for more papers by this authorProf. Hongkai Zhang
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Conceptualization (supporting), Data curation (supporting)
Search for more papers by this authorProf. Qian Liu
Department of Urology, Tianjin First Central Hospital, 300192 Tianjin, China
Contribution: Data curation (supporting), Software (supporting)
Search for more papers by this authorCorresponding Author
Prof. Yunxiang Lei
School of Chemistry and Materials Engineering, Wenzhou University, 325035 Wenzhou, China
Contribution: Visualization (lead), Writing - review & editing (supporting)
Search for more papers by this authorCorresponding Author
Prof. Dan Ding
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Funding acquisition (lead), Writing - review & editing (lead)
Search for more papers by this authorYufan Zhang
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
These authors contributed equally to this work.
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (lead), Writing - original draft (lead)
Search for more papers by this authorJisen Li
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
These authors contributed equally to this work.
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal)
Search for more papers by this authorJiliang Zhao
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Investigation (equal), Methodology (equal)
Search for more papers by this authorXuefei Li
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Investigation (equal), Methodology (equal)
Search for more papers by this authorZhimei Wang
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Conceptualization (supporting), Software (equal)
Search for more papers by this authorYicheng Huang
School of Chemistry and Materials Engineering, Wenzhou University, 325035 Wenzhou, China
Contribution: Investigation (supporting), Methodology (supporting)
Search for more papers by this authorProf. Hongkai Zhang
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Conceptualization (supporting), Data curation (supporting)
Search for more papers by this authorProf. Qian Liu
Department of Urology, Tianjin First Central Hospital, 300192 Tianjin, China
Contribution: Data curation (supporting), Software (supporting)
Search for more papers by this authorCorresponding Author
Prof. Yunxiang Lei
School of Chemistry and Materials Engineering, Wenzhou University, 325035 Wenzhou, China
Contribution: Visualization (lead), Writing - review & editing (supporting)
Search for more papers by this authorCorresponding Author
Prof. Dan Ding
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, 300071 Tianjin, China
Contribution: Funding acquisition (lead), Writing - review & editing (lead)
Search for more papers by this authorGraphical Abstract
In this study, benzo[c][1,2,5] thiadiazole/phenyl(pyridin-2-yl)methanone (BT/PPO)-doped long-wavelength (600 nm) room-temperature phosphorescent (RTP) material has been synthesized. The BT/PPO nanoparticles exhibit long-wavelength afterglow luminescence of 120 s, with a maximum penetration depth of 10 mm. Additionally, the potential of BT/PPO nanoparticles for detecting atherosclerotic plaques has been demonstrated.
Abstract
Room-temperature phosphorescent (RTP) materials have great potential for in vivo imaging because they can circumvent the autofluorescence of biological tissues. In this study, a class of organic-doped long-wavelength (≈600 nm) RTP materials with benzo[c][1,2,5] thiadiazole as a guest was constructed. Both host and guest molecules have simple structures and can be directly purchased commercially at a low cost. Owing to the long phosphorescence wavelength of the doping system, it exhibited good tissue penetration (10 mm). Notably, these RTP nanoparticles were successfully used to image atherosclerotic plaques, with a signal-to-background ratio (SBR) of 44.52. This study provides a new approach for constructing inexpensive red organic phosphorescent materials and a new method for imaging cardiovascular diseases using these materials.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
Supporting Information
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
| Filename | Description |
|---|---|
| anie202313890-sup-0001-BT.cif.res3.3 KB | Supporting Information |
| anie202313890-sup-0001-misc_information.pdf783 KB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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