Volume 61, Issue 1 e202116134
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Back Cover: A Biomimetic Approach for Spatially Controlled Cell Membrane Engineering Using Fusogenic Spherical Nucleic Acid (Angew. Chem. Int. Ed. 1/2022)

Minjie Lin

Minjie Lin

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

These authors contributed equally to this work.

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Yuanyuan Chen

Yuanyuan Chen

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

These authors contributed equally to this work.

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Sisi Zhao

Sisi Zhao

Institute of Chemical Biology and Nanomedicine, College of Biology, Hunan University, Changsha, 410082 China

These authors contributed equally to this work.

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Rui Tang

Rui Tang

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

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Prof. Dr. Zhou Nie

Prof. Dr. Zhou Nie

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

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Prof. Dr. Hang Xing

Corresponding Author

Prof. Dr. Hang Xing

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

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First published: 06 December 2021
Citations: 2

Graphical Abstract

Fusion of extracellular vesicles to cells contributes to many critical biological pathways. Inspired by the natural fusion process, Hang Xing and co-workers developed a liposome fusion-based transport strategy, termed LiFT, that enables the incorporation of a variety of functional moieties onto both external and internal cell membrane surfaces with precise orientation control (e202111647). By using LiFT, asymmetric DNA modifications with orthogonal functionalities on each side of the cell membrane were achieved, realizing applications such as heterotypic cell assembly and intracellular metabolite detection.

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