Sequences of Sequences: Spatial Organization of Coded Matter through Layer-by-Layer Assembly of Digital Polymers
Dr. Roza Szweda
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorMichel Tschopp
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorDr. Olivier Felix
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorCorresponding Author
Prof. Gero Decher
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorCorresponding Author
Dr. Jean-François Lutz
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorDr. Roza Szweda
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorMichel Tschopp
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorDr. Olivier Felix
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorCorresponding Author
Prof. Gero Decher
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorCorresponding Author
Dr. Jean-François Lutz
Université de Strasbourg, CNRS, Institut Charles Sadron UPR22, 23 rue du Loess, 67034 Strasbourg Cedex 2, France
Search for more papers by this authorGraphical Abstract
Thin films containing segregated layers of digitally encoded polymers were prepared and characterized. An ASCII-encoded sentence of 160 bytes was stored in these films using a library of 16 different digital polyanions. The results show that abiotic coded matter can be organized in precise nanoscale morphologies.
Abstract
A library of 16 digitally encoded polyanions was used in a layer-by-layer (LbL) polyelectrolyte assembly to nanofabricate thin films containing digitally coded strata. The polyanions were digital polyphosphodiesters (d-PPDE) prepared via an automated phosphoramidite process. Each component of the library contained 10 bytes of ASCII-encoded text (i.e. 80 coded monomers); thus the entire library allows the writing of a full sentence, which can be stored in a multilayer film as a sequence of sequences. To prepare fully segregated digital domains, non-coded layers composed of poly(allylamine hydrochloride) (PAH)/poly(sodium 4-styrenesulfonate) (PSS) were included between the d-PPDE coded layers as an intermediate barrier. Detailed analysis of the film homogeneity indicated formation of 70 nm-thick films in which digital layers are kept apart from another by non-coded interlayers. As a result, the sequence-coded polymer library could be piled-up in a defined sequence of layers.
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