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What Do Reactive Fragments Actually Do in Cells?

Corresponding Author

Prof. Dr. Oliver Plettenburg

[email protected]

orcid.org/0000-0001-9671-278X

Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Institute of Medicinal Chemistry, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany

Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany

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Prof. Dr. Oliver Plettenburg,

Corresponding Author

Prof. Dr. Oliver Plettenburg

[email protected]

orcid.org/0000-0001-9671-278X

Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Institute of Medicinal Chemistry, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany

Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany

Search for more papers by this author

First published: 09 December 2016

https://doi.org/10.1002/anie.201607914

Citations: 3

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Graphical Abstract

Covalently binding molecules are frequently regarded as being generally promiscuous. In a recent study, binding selectivities and cellular target proteins of a wide variety of reactive fragments are examined in a proteome-wide context.

References

1
1aJ. Singh, R. C. Petter, T. A. Baillie, A. Whitty, Nat. Rev. Drug Discovery 2011, 10, 307–317;
10.1038/nrd3410
CAS PubMed Web of Science® Google Scholar
1bC. González-Bello, ChemMedChem 2016, 11, 22–30.
10.1002/cmdc.201500469
CAS PubMed Web of Science® Google Scholar
2U. P. Dahal, R. S. Obach, A. M. Gilbert, Chem. Res. Toxicol. 2013, 26, 1739–1745.
10.1021/tx400301q
CAS PubMed Web of Science® Google Scholar
3S. G. Kathman, A. V. Statsyuk, MedChemComm 2016, 7, 576–585.
10.1039/C5MD00518C
CAS PubMed Web of Science® Google Scholar
4R. M. Miller, V. O. Paavilainen, S. Krishnan, I. M. Serafimova, J. Taunton, J. Am. Chem. Soc. 2013, 135, 5298–5301.
10.1021/ja401221b
CAS PubMed Web of Science® Google Scholar
5M. E. Flanagan, J. A. Abramite, D. P. Anderson, A. Aulabaugh, U. P. Dahal, A. M. Gilbert, C. Li, J. Montgomery, S. R. Oppenheimer, T. Ryder, B. P. Schuff, D. P. Uccello, G. S. Walker, Y. Wu, M. F. Brown, J. M. Chen, M. M. Hayward, M. C. Noe, R. S. Obach, L. Philippe, V. Shanmugasundaram, M. J. Shapiro, J. Starr, J. Stroh, Y. Che, J. Med. Chem. 2014, 57, 10072–10079.
10.1021/jm501412a
CAS PubMed Web of Science® Google Scholar
6
6aN. London, R. M. Miller, S. Krishnan, K. Uchida, J. J. Irwin, O. Eidam, L. Gibold, P. Cimermancic, R. Bonnet, B. K. Shoichet, J. Taunton, Nat. Chem. Biol. 2014, 10, 1066–1072;
10.1038/nchembio.1666
CAS PubMed Web of Science® Google Scholar
6bH. M. Kumalo, S. Bhakat, M. E. Soliman, Molecules 2015, 20, 1984–2000.
10.3390/molecules20021984
PubMed Web of Science® Google Scholar
7S. G. Kathman, Z. Xu, A. V. Statsyuk, J. Med. Chem. 2014, 57, 4969–4974.
10.1021/jm500345q
CAS PubMed Web of Science® Google Scholar
8C. Jöst, C. Nitsche, T. Scholz, L. Roux, C. D. Klein, J. Med. Chem. 2014, 57, 7590–7599.
10.1021/jm5006918
CAS PubMed Web of Science® Google Scholar
9K. M. Backus, B. E. Correia, K. M. Lum, S. Forli, B. D. Horning, G. E. Gonzalez-Paez, S. Chatterjee, B. R. Lanning, J. R. Teijaro, A. J. Olson, D. W. Wolan, B. F. Cravatt, Nature 2016, 534, 570–574.
10.1038/nature18002
CAS PubMed Web of Science® Google Scholar
10S. E. Ong, B. Blagoev, I. Kratchmarova, D. B. Kristensen, H. Steen, A. Pandey, M. Mann, Mol. Cell. Proteomics 2002, 1, 376–386.
10.1074/mcp.M200025-MCP200
CAS PubMed Web of Science® Google Scholar
11E. Weerapana, C. Wang, G. M. Simon, F. Richter, S. Khare, M. B. D. Dillon, D. A. Bachovchin, K. Mowen, D. Baker, B. F. Cravatt, Nature 2010, 468, 790-U779.
10.1038/nature09472
CAS PubMed Web of Science® Google Scholar
12A. S. Kalgutkar, D. K. Dalvie, Expert Opin. Drug Discovery 2012, 7, 561–581.
10.1517/17460441.2012.688744
CAS PubMed Web of Science® Google Scholar

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Volume56, Issue2

January 9, 2017

Pages 446-448

What Do Reactive Fragments Actually Do in Cells?

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What Do Reactive Fragments Actually Do in Cells?

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