Review
Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)†
Prof. Paul Modrich,
Corresponding Author
Prof. Paul Modrich
Howard Hughes Medical Institute and Department of Biochemistry, Duke University, Medical Center, Durham, NC, 27710 USA
Search for more papers by this authorProf. Paul Modrich,
Corresponding Author
Prof. Paul Modrich
Howard Hughes Medical Institute and Department of Biochemistry, Duke University, Medical Center, Durham, NC, 27710 USA
Search for more papers by this author†
Copyright© The Nobel Foundation 2015. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.
Graphical Abstract
DNA molecules are not completely stable, they are subject to chemical or photochemical damage and errors that occur during DNA replication resulting in mismatched base pairs. Through mechanistic studies Paul Modrich showed how replication errors are corrected by strand-directed mismatch repair in Escherichia coli and human cells.
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