Review
Nanoscopy with Focused Light (Nobel Lecture)†
Prof. Dr. Stefan W. Hell,
Corresponding Author
Prof. Dr. Stefan W. Hell
Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics, Am Fassberg 11, 37077 Göttingen (Germany)
German Cancer Research Center (DKFZ), Optical Nanoscopy Division, Im Neuenheimer Feld 280, 69120 Heidelberg (Germany)
Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this authorProf. Dr. Stefan W. Hell,
Corresponding Author
Prof. Dr. Stefan W. Hell
Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics, Am Fassberg 11, 37077 Göttingen (Germany)
German Cancer Research Center (DKFZ), Optical Nanoscopy Division, Im Neuenheimer Feld 280, 69120 Heidelberg (Germany)
Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics, Am Fassberg 11, 37077 Göttingen (Germany)Search for more papers by this author†
Copyright© The Nobel Foundation 2014. We thank the Nobel Foundation, Stockholm, for permission to print this lecture. Nobel Lecture, December 8, 2014 (Stockholm University), with an addition from the lecture on December 13, 2014 (Uppsala University).
Graphical Abstract
A picture is worth a thousand words—This doesn't only apply to everyday life but also to the natural sciences. It is, therefore, probably not by chance that the historical beginning of modern natural sciences very much coincides with the invention of light microscopy. S. W. Hell shows in his Nobel Lecture that the diffraction resolution barrier has been overcome by using molecular state transitions (e.g. on/off) to make nearby molecules transiently discernible.
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