Ligand-Promoted ortho-CH Amination with Pd Catalysts†
Dr. Dajian Zhu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Guoqiang Yang
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorJian He
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorLing Chu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Gang Chen
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Wei Gong
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Ke Chen
Chemical Development, 1 Squibb Drive, New Brunswick, NJ 08903 (USA)
Search for more papers by this authorDr. Martin D. Eastgate
Chemical Development, 1 Squibb Drive, New Brunswick, NJ 08903 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Jin-Quan Yu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)Search for more papers by this authorDr. Dajian Zhu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Guoqiang Yang
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorJian He
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorLing Chu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Gang Chen
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Wei Gong
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Ke Chen
Chemical Development, 1 Squibb Drive, New Brunswick, NJ 08903 (USA)
Search for more papers by this authorDr. Martin D. Eastgate
Chemical Development, 1 Squibb Drive, New Brunswick, NJ 08903 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Jin-Quan Yu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)Search for more papers by this authorWe gratefully acknowledge The Scripps Research Institute, and the U.S. NSF (CHE-1011898) for financial support. D.Z. is a visiting scholar from Huazhong University of Science and Technology, sponsored by the China Scholarship Council (201206165031). G.Y. thanks the Shanghai Jiao Tong University for HaiWai ShiZi ChuBei postdoctoral fellowship support.
Graphical Abstract
Trimethoxylpyridine is an efficient ligand for promoting Pd-catalyzed ortho-CH amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable PdII-catalyzed C
H activation reactions directed by weakly coordinating functional groups.
Abstract
2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-CH amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable PdII-catalyzed C
H activation reactions directed by weakly coordinating functional groups.
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