Palladium-Catalyzed Reductive Carbonylation of Aryl Halides with N-Formylsaccharin as a CO Source†
Dr. Tsuyoshi Ueda
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)
Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo Co., Ltd. 1-12-1 Shinomiya, Hiratsuka, Kanagawa 254-0014 (Japan)
Search for more papers by this authorDr. Hideyuki Konishi
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)
Search for more papers by this authorCorresponding Author
Prof. Dr. Kei Manabe
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)Search for more papers by this authorDr. Tsuyoshi Ueda
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)
Process Technology Research Laboratories, Pharmaceutical Technology Division, Daiichi Sankyo Co., Ltd. 1-12-1 Shinomiya, Hiratsuka, Kanagawa 254-0014 (Japan)
Search for more papers by this authorDr. Hideyuki Konishi
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)
Search for more papers by this authorCorresponding Author
Prof. Dr. Kei Manabe
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)Search for more papers by this authorThis research was supported by the Daiichi Sankyo Co., Ltd.
Graphical Abstract
Easy peasy: The title reaction employs N-formylsaccharin, which is an easily accessible crystalline compound, as an effective CO source. The reactions proceed with a small excess of the CO source at moderate temperatures and were successfully applied to a wide range of aryl bromides. DMF=N,N-dimethylformamide, dppb=1,4-bis-(diphenylphosphino)butane.
Supporting Information
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