On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes†
Andreas Meyer
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig (Germany) http://www.pharmchem.tu-bs.de/forschung/ott/
Search for more papers by this authorProf. Dr. Christoph P. Bagowski
Klinik für Innere Medizin, Ernst-Moritz Arndt University Greifswald, Friedrich Löffler Strasse 23a, 17475 Greifswald (Germany)
Search for more papers by this authorDr. Malte Kokoschka
Centre for Electrochemical Sciences-CES, Ruhr-Universität Bochum, 44780 Bochum (Germany)
Search for more papers by this authorDr. Maria Stefanopoulou
Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780 Bochum (Germany)
Search for more papers by this authorDr. Hamed Alborzinia
Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg (Germany)
Search for more papers by this authorSuzan Can
Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg (Germany)
Search for more papers by this authorM. Sc. Danielle H. Vlecken
Institute of Biology, Department of Molecular and Cellular Biology, University of Leiden, AL Leiden (The Netherlands)
Search for more papers by this authorProf. Dr. William S. Sheldrick
Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780 Bochum (Germany)
Search for more papers by this authorProf. Dr. Stefan Wölfl
Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg (Germany)
Search for more papers by this authorCorresponding Author
Prof. Dr. Ingo Ott
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig (Germany) http://www.pharmchem.tu-bs.de/forschung/ott/
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig (Germany) http://www.pharmchem.tu-bs.de/forschung/ott/Search for more papers by this authorAndreas Meyer
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig (Germany) http://www.pharmchem.tu-bs.de/forschung/ott/
Search for more papers by this authorProf. Dr. Christoph P. Bagowski
Klinik für Innere Medizin, Ernst-Moritz Arndt University Greifswald, Friedrich Löffler Strasse 23a, 17475 Greifswald (Germany)
Search for more papers by this authorDr. Malte Kokoschka
Centre for Electrochemical Sciences-CES, Ruhr-Universität Bochum, 44780 Bochum (Germany)
Search for more papers by this authorDr. Maria Stefanopoulou
Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780 Bochum (Germany)
Search for more papers by this authorDr. Hamed Alborzinia
Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg (Germany)
Search for more papers by this authorSuzan Can
Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg (Germany)
Search for more papers by this authorM. Sc. Danielle H. Vlecken
Institute of Biology, Department of Molecular and Cellular Biology, University of Leiden, AL Leiden (The Netherlands)
Search for more papers by this authorProf. Dr. William S. Sheldrick
Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780 Bochum (Germany)
Search for more papers by this authorProf. Dr. Stefan Wölfl
Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg (Germany)
Search for more papers by this authorCorresponding Author
Prof. Dr. Ingo Ott
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig (Germany) http://www.pharmchem.tu-bs.de/forschung/ott/
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig (Germany) http://www.pharmchem.tu-bs.de/forschung/ott/Search for more papers by this authorFinancial support by the Deutsche Forschungsgemeinschaft (DFG, project FOR630), the EU, and the state of North Rhine Westphalia in the framework of the HighTech.NRW is gratefully acknowledged.
Graphical Abstract
Golden times for metal-based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influence tumor cell metabolism, mitochondrial respiration, and angiogenesis in zebrafish embryos.
Supporting Information
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