Communication

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin^†

Dr. François Lévesque

Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

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Prof. Dr. Peter H. Seeberger,

Corresponding Author

Prof. Dr. Peter H. Seeberger

[email protected]

Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany) http://www.mpikg.mpg.de

Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)Search for more papers by this author

Dr. François Lévesque,

Dr. François Lévesque

Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

Search for more papers by this author

Prof. Dr. Peter H. Seeberger,

Corresponding Author

Prof. Dr. Peter H. Seeberger

[email protected]

Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany) http://www.mpikg.mpg.de

Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)Search for more papers by this author

First published: 16 January 2012

https://doi.org/10.1002/anie.201107446

Citations: 485

^†

We thank the Max-Planck Society for generous financial support. F.L. is the recipient of a postdoctoral fellowship from Fonds québécois de la recherche sur la nature et les technologies (FQRNT). Vapourtec is gratefully acknowledged for providing R2C+ and R4 flow-chemistry systems. We thank Dr. V. Mountain for critically editing this manuscript and Ms. C. Steininger for drawing Figure 1.

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Graphical Abstract

Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.

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Volume51, Issue7

February 13, 2012

Pages 1706-1709

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin^†

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Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin^†