Modulating PNA/DNA Hybridization by Light†
Corresponding Author
Dr. Thorsten Stafforst
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.chSearch for more papers by this authorCorresponding Author
Prof. Dr. Donald Hilvert
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.chSearch for more papers by this authorCorresponding Author
Dr. Thorsten Stafforst
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.chSearch for more papers by this authorCorresponding Author
Prof. Dr. Donald Hilvert
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich (Switzerland), Fax: (+41) 44-632-1486 http://www.protein.ethz.chSearch for more papers by this authorThis work was generously supported by the Deutsche Akademie der Naturforscher Leopoldina (Bundesministerium für Bildung und Forschung BMBF-LPD 9901/8-158) and the ETH Zürich.
Graphical Abstract
Turn it on! Hybridization of peptide nucleic acids with DNA can be efficiently manipulated by modifying the PNA with a single azobenzene photoswitch. The effect is remarkably strong in the triplex binding mode and can be exploited for the photocontrol of transcription by T7 RNA polymerase (Pol T7).
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