“On-Off” Multivalent Recognition: Degradable Dendrons for Temporary High-Affinity DNA Binding†
Daniel J. Welsh
Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44) 1904-432-516, http://www.york.ac.uk/depts/chem/staff/dks.html
Search for more papers by this authorSimon P. Jones Dr.
Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44) 1904-432-516, http://www.york.ac.uk/depts/chem/staff/dks.html
Search for more papers by this authorDavid K. Smith Prof.
Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44) 1904-432-516, http://www.york.ac.uk/depts/chem/staff/dks.html
Search for more papers by this authorDaniel J. Welsh
Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44) 1904-432-516, http://www.york.ac.uk/depts/chem/staff/dks.html
Search for more papers by this authorSimon P. Jones Dr.
Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44) 1904-432-516, http://www.york.ac.uk/depts/chem/staff/dks.html
Search for more papers by this authorDavid K. Smith Prof.
Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44) 1904-432-516, http://www.york.ac.uk/depts/chem/staff/dks.html
Search for more papers by this authorWe acknowledge financial support from EPSRC (EP/C534395/1).
Graphical Abstract
Now you bind it—now you don't! Chemical degradation of a dendritic scaffold allows multivalent interactions with DNA to be “switched off” as the multivalent array of ligands breaks down into smaller fragments, offering an approach by which a molecule can be temporarily endowed with high affinity for a biological target—an important concept in the development of new synthetic systems to intervene in biological pathways.
Abstract
Now you bind it—now you don't! Chemical degradation of a dendritic scaffold allows multivalent interactions with DNA to be “switched off” as the multivalent array of ligands breaks down into smaller fragments, offering an approach by which a molecule can be temporarily endowed with high affinity for a biological target—an important concept in the development of new synthetic systems to intervene in biological pathways.
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