Volume 47, Issue 46 pp. 8856-8858

Communication

Intermolecular Sensitization of a Terbium-Containing Amphiphile by an Integral Membrane Protein^†

Catherine L. Davies,

Catherine L. Davies

Department of Chemistry, University of York, York YO10 5DD (UK), Fax: (+44) 1904-432-587

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Nicholas G. Housden Dr.,

Nicholas G. Housden Dr.

Department of Biology, University of York (UK)

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Anne-K. Duhme-Klair Dr.,

Anne-K. Duhme-Klair Dr.

[email protected]

Department of Chemistry, University of York, York YO10 5DD (UK), Fax: (+44) 1904-432-587

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Catherine L. Davies,

Catherine L. Davies

Department of Chemistry, University of York, York YO10 5DD (UK), Fax: (+44) 1904-432-587

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Nicholas G. Housden Dr.,

Nicholas G. Housden Dr.

Department of Biology, University of York (UK)

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Anne-K. Duhme-Klair Dr.,

Anne-K. Duhme-Klair Dr.

[email protected]

Department of Chemistry, University of York, York YO10 5DD (UK), Fax: (+44) 1904-432-587

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First published: 28 October 2008

https://doi.org/10.1002/anie.200803828

Citations: 10

^†

We thank Prof. R. N. Perutz and Prof. C. Kleanthous for helpful discussions, M. Stark for the TEM image, Prof. S. Faulkner, Dr. H. D. Batey, and R. Bradshaw (University of Manchester) for the lifetime determinations, and the EPSRC and the University of York for financial support.

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Graphical Abstract

A luminescent probe for integral membrane proteins (IMPs): Intermolecular sensitization of Tb luminescence is observed in micelles in which the polar head group of a Tb-containing lipid analogue is located close to an antenna chromophore, such as tryptophan, in a surfactant analogue that mimics interfacially bound tryptophan residues of an IMP or tryptophan in the aromatic collar of the vitamin B₁₂ transporter protein BtuB (see picture).

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Volume47, Issue46

November 3, 2008

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Intermolecular Sensitization of a Terbium-Containing Amphiphile by an Integral Membrane Protein^†

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Intermolecular Sensitization of a Terbium-Containing Amphiphile by an Integral Membrane Protein^†