Volume 44, Issue 37 pp. 6054-6057
Communication

Fluorescence Resonant Energy Transfer Biosensor Based on Upconversion-Luminescent Nanoparticles

Leyu Wang

Leyu Wang

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

Anhui Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, P.R. China

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Ruoxue Yan

Ruoxue Yan

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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Ziyang Huo

Ziyang Huo

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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Lun Wang Prof.

Lun Wang Prof.

Anhui Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, P.R. China

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Jinghui Zeng Dr.

Jinghui Zeng Dr.

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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Jie Bao

Jie Bao

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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Xun Wang Dr.

Xun Wang Dr.

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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Qing Peng Dr.

Qing Peng Dr.

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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Yadong Li Prof. Dr.

Yadong Li Prof. Dr.

Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China

National Center for Nanoscience and Nanotechnology, Beijing, 100084, P.R. China, Fax: (+86) 10-6278-8765

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First published: 14 September 2005
Citations: 844

This work was supported by the NSFC (90406003, 50372030, 20131030, 20401010), the Specialized Research Fund for the Doctoral Program of Higher Education, the Foundation for the Authors of National Excellent Doctoral Dissertation of P.R. China, and the State Key Project of Fundamental Research for Nanomaterials and Nanostructures (2003CB716901).

Graphical Abstract

A pair to fret about: Biotinylated phosphor nanoparticles that emit upconversion luminescence have been taken with biotinylated Au nanoparticles, which act as energy acceptors, and the pair has been applied to the determination of trace amounts of avidin based on fluorescence resonant energy transfer (FRET; see picture).

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