The Ubiquitin System for Protein Degradation and Some of Its Roles in the Control of the Cell-Division Cycle (Nobel Lecture)†
Avram Hershko
Unit of Biochemistry the B. Rappaport Faculty of Medicine , Technion-Israel Institute for Technology, Haifa 31096, Israel, Fax: (+972) 4-855-2296
Rappaport Institute for Research in the Medical Sciences, Technion-Israel Institute for Technology, Haifa 31096, Israel, Fax: (+972) 4-855-2296
Search for more papers by this authorAvram Hershko
Unit of Biochemistry the B. Rappaport Faculty of Medicine , Technion-Israel Institute for Technology, Haifa 31096, Israel, Fax: (+972) 4-855-2296
Rappaport Institute for Research in the Medical Sciences, Technion-Israel Institute for Technology, Haifa 31096, Israel, Fax: (+972) 4-855-2296
Search for more papers by this authorCopyright© The Nobel Foundation 2004. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.
Abstract
Protein breakdown is an exact, controlled process in which the protein molecule ubiquitin plays a decisive role by binding to a protein and labeling it for breakdown. The cellular mechanisms of this process are widely known today thanks to the work of the 2004 Nobel Laureates Irwin Rose, Avram Hershko, and Aaron Ciechanover. The Laureates report at first hand in their Nobel Lectures.
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