A Diversity-Oriented Synthesis of α-Amino Acid Derivatives by a Silyltelluride-Mediated Radical Coupling Reaction of Imines and Isonitriles†
Shigeru Yamago Prof.
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorHiroshi Miyazoe Dr.
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorTakeyoshi Nakayama
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorMasaki Miyoshi
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorJunichi Yoshida Prof.
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorShigeru Yamago Prof.
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorHiroshi Miyazoe Dr.
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorTakeyoshi Nakayama
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorMasaki Miyoshi
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorJunichi Yoshida Prof.
Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Kyoto 606-8501, Japan, Fax: (+81) 75-753-5911
Search for more papers by this authorThis work was partly supported by a Grant-in-Aid for the Scientific Research from Japan Society for the Promotion of Science.
Graphical Abstract
A radical idea: A diversity-oriented synthesis of α-amino acid derivatives is realized by the silyltelluride-mediated radical coupling of imines and isonitriles followed by various transformations of the carbon–tellurium bond of the coupling products (see scheme). The α-amino radical generated from the imine and the silyltelluride is the key intermediate in the coupling reaction.
Supporting Information
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