Communication

Bioactive Protein Nanoarrays on Nickel Oxide Surfaces Formed by Dip-Pen Nanolithography^†

Jwa-Min Nam

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

These authors contributally equally to this work.

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Sang Woo Han Dr.,

Sang Woo Han Dr.

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

These authors contributally equally to this work.

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Ki-Bum Lee,

Ki-Bum Lee

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

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Xiaogang Liu,

Xiaogang Liu

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

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Mark A. Ratner,

Mark A. Ratner

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

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Chad A. Mirkin Prof.,

Chad A. Mirkin Prof.

[email protected]

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

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Jwa-Min Nam,

Jwa-Min Nam

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

These authors contributally equally to this work.

Search for more papers by this author

Sang Woo Han Dr.,

Sang Woo Han Dr.

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

These authors contributally equally to this work.

Search for more papers by this author

Ki-Bum Lee,

Ki-Bum Lee

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

Search for more papers by this author

Xiaogang Liu,

Xiaogang Liu

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

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Mark A. Ratner,

Mark A. Ratner

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

Search for more papers by this author

Chad A. Mirkin Prof.,

Chad A. Mirkin Prof.

[email protected]

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA, Fax: (+1) 847-467-5123

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First published: 25 February 2004

https://doi.org/10.1002/anie.200353203

Citations: 110

^†

C.A.M. and M.A.R. acknowledge the National Sciences Foundation NSEC program and the Department of Defence MURI/DURINT program for support of this research. S.W.H. acknowledges KOSEF for support of a postdoctoral fellowship.

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Graphical Abstract

Ink flowing from a pen: Direct-write dip-pen nanolithography of His-tagged proteins (ubiquitin and thioredoxin) has been used to generate biologically active protein nanoarrays with feature sizes as small as 80 nm on nickel oxide surfaces without the need for an applied electric field. The protein molecules in this system seem to diffuse from the Ni-coated atomic force microscopy (AFM) tips to the Ni-coated substrate (see diagram).

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Volume43, Issue10

February 27, 2004

Pages 1246-1249

Bioactive Protein Nanoarrays on Nickel Oxide Surfaces Formed by Dip-Pen Nanolithography^†

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Bioactive Protein Nanoarrays on Nickel Oxide Surfaces Formed by Dip-Pen Nanolithography†

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Bioactive Protein Nanoarrays on Nickel Oxide Surfaces Formed by Dip-Pen Nanolithography^†