Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease
Dr. Tianfu Zhang
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
These authors contributed equally to this work.
Contribution: Conceptualization (lead), Methodology (lead), Writing - original draft (lead), Writing - review & editing (lead)
Search for more papers by this authorXiaoyu Chen
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
These authors contributed equally to this work.
Contribution: Methodology (equal)
Search for more papers by this authorDr. Congmin Yuan
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Contribution: Methodology (supporting), Software (supporting)
Search for more papers by this authorProf. Xiaobin Pang
Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorPing Shangguan
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorYisheng Liu
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorLulu Han
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorProf. Jianwei Sun
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Contribution: Writing - review & editing (supporting)
Search for more papers by this authorDr. Jacky W. Y. Lam
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Contribution: Supervision (supporting), Writing - review & editing (supporting)
Search for more papers by this authorDr. Yang Liu
Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, 475004 Kaifeng, China
Contribution: Writing - review & editing (supporting)
Search for more papers by this authorCorresponding Author
Dr. Jiefei Wang
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Funding acquisition (supporting), Methodology (supporting), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Bingyang Shi
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Centre for motor neuron disease, Macquarie Medical School, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia
Contribution: Funding acquisition (equal), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Ben Zhong Tang
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, 518172 Shenzhen, Guangdong, China
Contribution: Funding acquisition (lead), Project administration (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorDr. Tianfu Zhang
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
These authors contributed equally to this work.
Contribution: Conceptualization (lead), Methodology (lead), Writing - original draft (lead), Writing - review & editing (lead)
Search for more papers by this authorXiaoyu Chen
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
These authors contributed equally to this work.
Contribution: Methodology (equal)
Search for more papers by this authorDr. Congmin Yuan
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Contribution: Methodology (supporting), Software (supporting)
Search for more papers by this authorProf. Xiaobin Pang
Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorPing Shangguan
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorYisheng Liu
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorLulu Han
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Methodology (supporting)
Search for more papers by this authorProf. Jianwei Sun
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Contribution: Writing - review & editing (supporting)
Search for more papers by this authorDr. Jacky W. Y. Lam
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Contribution: Supervision (supporting), Writing - review & editing (supporting)
Search for more papers by this authorDr. Yang Liu
Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, 475004 Kaifeng, China
Contribution: Writing - review & editing (supporting)
Search for more papers by this authorCorresponding Author
Dr. Jiefei Wang
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Contribution: Funding acquisition (supporting), Methodology (supporting), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Bingyang Shi
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, 475004 Kaifeng, China
Centre for motor neuron disease, Macquarie Medical School, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia
Contribution: Funding acquisition (equal), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Ben Zhong Tang
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, 518172 Shenzhen, Guangdong, China
Contribution: Funding acquisition (lead), Project administration (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorAbstract
Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent β-amyloid (Aβ) fibrosis encounter failures due to the blood–brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near-infrared (NIR) aggregation-induced emission (AIE) probe, DNTPH, via balanced hydrophobicity-hydrophilicity strategy. DNTPH binds selectively to Aβ fibrils with a high signal-to-noise ratio. In vivo imaging revealed its excellent BBB permeability and long-term tracking ability with high-performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on Aβ fibrosis and promotes fibril disassembly, thereby attenuating Aβ-induced neurotoxicity. DNTPH treatment significantly reduced Aβ plaques and rescued learning deficits in AD mice. Thus, DNTPH serves as the first AIE in vivo theranostic agent for real-time NIR imaging of Aβ plaques and AD therapy simultaneously.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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