Volume 134, Issue 1 e202116134
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Rücktitelbild: A Biomimetic Approach for Spatially Controlled Cell Membrane Engineering Using Fusogenic Spherical Nucleic Acid (Angew. Chem. 1/2022)

Minjie Lin

Minjie Lin

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

These authors contributed equally to this work.

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Yuanyuan Chen

Yuanyuan Chen

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

These authors contributed equally to this work.

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Sisi Zhao

Sisi Zhao

Institute of Chemical Biology and Nanomedicine, College of Biology, Hunan University, Changsha, 410082 China

These authors contributed equally to this work.

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Rui Tang

Rui Tang

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

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Prof. Dr. Zhou Nie

Prof. Dr. Zhou Nie

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

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Prof. Dr. Hang Xing

Corresponding Author

Prof. Dr. Hang Xing

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China

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First published: 06 December 2021

Graphical Abstract

Die Fusion extrazellulärer Vesikel mit der Zelle trägt zu vielen kritischen biologischen Prozessen bei. In Anlehnung an den natürlichen Fusionsprozess haben Hang Xing et al. eine auf der Liposomenfusion basierende Transportstrategie entwickelt (LiFT), die es ermöglicht, eine Vielzahl von funktionellen Komponenten auf der äußeren und inneren Zellmembranoberfläche anzubringen (e202111647). Mittels LiFT werden asymmetrische DNA-Modifikationen mit orthogonalen Funktionalitäten auf jeder Seite der Zellmembran demonstriert, wodurch Anwendungen wie der heterotypische Zellaufbau und der Nachweis intrazellulärer Metaboliten möglich werden.

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