Macrocycle Dynamics in a Branched [8]Catenane Controlled by Three Different Stimuli in Three Different Regions
Antony Wing Hung Ng
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorSamuel Kin-Man Lai
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorChi-Chung Yee
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorCorresponding Author
Dr. Ho Yu Au-Yeung
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorAntony Wing Hung Ng
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorSamuel Kin-Man Lai
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorChi-Chung Yee
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorCorresponding Author
Dr. Ho Yu Au-Yeung
State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Search for more papers by this authorAbstract
A branched [8]catenane from an efficient one-pot synthesis (72 % HPLC yield, 59 % isolated yield) featuring the simultaneous use of three kinds of templates and cucurbit[6]uril-mediated azide–alkyne cycloaddition (CBAAC) for ring-closing is reported. Design and assembly of the [8]catenane precursors are unexpectedly complex that can involve cooperating, competing and non-influencing interactions. Due to the branched structure, dynamics of the [8]catenane can be modulated in different extent by rigidifying/loosening the mechanical bonds at different regions by using solvent polarity, acid-base and metal ions as the stimuli. This work not only highlights the importance of understanding the delicate interplay of the weak and non-obvious supramolecular interactions in the synthesis of high-order [n]catenane, but also demonstrates a complex control of dynamics and flexibility for exploiting [n]catenanes applications.
Conflict of interest
The authors declare no conflict of interest.
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