Palladium(0)-Catalyzed Intermolecular Amination of Unactivated C
H Bonds†
Dr. Jun Pan
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
Search for more papers by this authorMingjuan Su
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Stephen L. Buchwald
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Search for more papers by this authorDr. Jun Pan
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
Search for more papers by this authorMingjuan Su
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Stephen L. Buchwald
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)Search for more papers by this authorGenerous financial support from the National Institutes of Health (GM-46059) is gratefully acknowledged. The Bruker 400 MHz instrument used in this work was purchased with funding from the National Institutes of Health (GM 1S10RR13886-01). We are grateful to Georgiy Teverovskiy (MIT) for initial studies on DFT calculations and to Sophie Rousseaux (MIT) for helpful discussions.
Graphical Abstract
Auf die eine oder andere Weise: Die Titelreaktion nichtaktivierter C
-H-Bindungen mit Arylaminen wird untersucht (siehe Schema; dba=Dibenzylidenaceton, Tf=Trifluormethansulfonyl). Durch Einstellen der sterischen Eigenschaften des Substrats kann entweder das C-N-Kreuzkupplungsprodukt oder das C-H-Aminierungsprodukt selektiv erhalten werden.
Supporting Information
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