Enantioselective Cobalt-Catalyzed Preparation of Trifluoromethyl-Substituted Cyclopropanes†
Bill Morandi
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.ch
Search for more papers by this authorDr. Brian Mariampillai
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.ch
Search for more papers by this authorCorresponding Author
Prof. Dr. Erick M. Carreira
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.chSearch for more papers by this authorBill Morandi
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.ch
Search for more papers by this authorDr. Brian Mariampillai
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.ch
Search for more papers by this authorCorresponding Author
Prof. Dr. Erick M. Carreira
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland), Fax: (+41) 1-632-1328 http://www.carreira.ethz.chSearch for more papers by this authorWe are grateful to the Swiss National Foundation and the SSCI for a fellowship to B. Morandi and a NSERC post-doctoral fellowship to B. Mariampillai. Dr. Schweizer is acknowledged for X-ray analysis.
Graphical Abstract
Leichter Zugang auf Wasser: Eine Cobalt-katalysierte asymmetrische Synthese von Trifluormethylcyclopropanen wurde entwickelt, die mit einer breiten Palette von Styrolen hohe Enantiomerenüberschüsse ergibt (siehe Schema). Die Reaktion bietet einen neuen Zugang zu enantiomerenangereicherten CF3-Bausteinen.
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