Single-Molecule Covalent Chemistry with Spatially Separated Reactants†
Tudor Luchian
Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
These authors contributed equally to this work.
Search for more papers by this authorSeong-Ho Shin
Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
These authors contributed equally to this work.
Search for more papers by this authorHagan Bayley
Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
Search for more papers by this authorTudor Luchian
Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
These authors contributed equally to this work.
Search for more papers by this authorSeong-Ho Shin
Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
These authors contributed equally to this work.
Search for more papers by this authorHagan Bayley
Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
Search for more papers by this authorThis work was supported by the Office of Naval Research, the U.S. Department of Energy, the Multidisciplinary University Research Initiative (ONR-1999), and the National Institutes of Health. We thank Sean Conlan for help with molecular modeling.
Graphical Abstract
Proteinporen als Nanoreaktoren konnten kürzlich eingesetzt werden, um die reversible kovalente Chemie einer einfachen Reaktion auf Einzelmolekül-Ebene anhand des Stroms durch die Pore zu beobachten. Jetzt ist es gelungen, eine mehrstufige Reaktion zu beobachten, bei der zwei der Reaktanten durch die Membran, welche die Pore enthält, getrennt sind und in die Reaktionszone diffundieren (siehe Bild).
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