Limb anomalies following chorionic villus sampling: A registry based case-control study
Corresponding Author
Pierpaolo Mastroiacovo
Birth Defect Unit of the Department of Pediatrics, Catholic University, Rome, Italy
ICARO–ASM, Rome, Italy
Birth Defects Unit, Clinica Pediatrica Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, 00168 Roma, ITALYSearch for more papers by this authorLorenzo Davide Botto
Birth Defect Unit of the Department of Pediatrics, Catholic University, Rome, Italy
ICARO–ASM, Rome, Italy
Search for more papers by this authorDante Baronciani
Division of Neonatology, Hospital of Lecco, Italy
Search for more papers by this authorAnna Chiara Cigolotti
Department of Pediatrics, University of Torino at Novara, Italy
Search for more papers by this authorSergio Giordano
Division of Pediatrics, Hospital of Verbania, Italy
Search for more papers by this authorFrancesco Puppin
Division of Pediatrics, Hospital of Pordenone, Italy
Search for more papers by this authorCorresponding Author
Pierpaolo Mastroiacovo
Birth Defect Unit of the Department of Pediatrics, Catholic University, Rome, Italy
ICARO–ASM, Rome, Italy
Birth Defects Unit, Clinica Pediatrica Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, 00168 Roma, ITALYSearch for more papers by this authorLorenzo Davide Botto
Birth Defect Unit of the Department of Pediatrics, Catholic University, Rome, Italy
ICARO–ASM, Rome, Italy
Search for more papers by this authorDante Baronciani
Division of Neonatology, Hospital of Lecco, Italy
Search for more papers by this authorAnna Chiara Cigolotti
Department of Pediatrics, University of Torino at Novara, Italy
Search for more papers by this authorSergio Giordano
Division of Pediatrics, Hospital of Verbania, Italy
Search for more papers by this authorFrancesco Puppin
Division of Pediatrics, Hospital of Pordenone, Italy
Search for more papers by this authorAbstract
Using data from the Italian Multicentric Birth Defect Registry a case–control study was performed to verify if chorionic villus sampling (CVS) was associated with transverse limb defects (TLD), with or without features of oro–mandibular–limb hypogenesis complex (OMLHC), in the exposed offspring. The results show that the risk of TLD and OMLHC is increased following CVS, and is particularly high for CVS performed early in pregnancy, i.e., under 70 days of gestational age.
These results, together with a review of other epidemiologic studies, biological data and clinical reports, strongly suggest a causative role of CVS as a risk factor for TLD and indicate that at this stage CVS before 70 days of gestational age should be discouraged as an option for prenatal diagnosis and that all patients wishing to undergo CVS should be informed about the possible risk of the procedure. © 1992 Wiley-Liss, Inc.
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