Non-random association between DNA markers and Huntington disease locus in the Italian population
Corresponding Author
Andrea Novelletto
Dipartimento di Biologia, Università Tor Vergata, Roma, Italy
Dipartimento di Biologia, Università Tor Vergata, Via O. Raimondo 00173 Roma, ItalySearch for more papers by this authorPaola Mandich
Cattedra di Genetica Medica, ISMI, Università di Genova, Italy
Search for more papers by this authorEmilia Bellone
Cattedra di Genetica Medica, ISMI, Università di Genova, Italy
Search for more papers by this authorPatrizia Malaspina
Dipartimento di Biologia, Università Tor Vergata, Roma, Italy
Search for more papers by this authorGiuseppa Vivona
Dipartimento di Sanità e Biologia Cellulare, Università Tor Vergata, Roma, Italy
Search for more papers by this authorFranco Ajmar
Cattedra di Genetica Medica, ISMI, Università di Genova, Italy
Search for more papers by this authorMarina Frontali
Istituto di Medicina Sperimentale, CNR, Roma, Italy
Search for more papers by this authorCorresponding Author
Andrea Novelletto
Dipartimento di Biologia, Università Tor Vergata, Roma, Italy
Dipartimento di Biologia, Università Tor Vergata, Via O. Raimondo 00173 Roma, ItalySearch for more papers by this authorPaola Mandich
Cattedra di Genetica Medica, ISMI, Università di Genova, Italy
Search for more papers by this authorEmilia Bellone
Cattedra di Genetica Medica, ISMI, Università di Genova, Italy
Search for more papers by this authorPatrizia Malaspina
Dipartimento di Biologia, Università Tor Vergata, Roma, Italy
Search for more papers by this authorGiuseppa Vivona
Dipartimento di Sanità e Biologia Cellulare, Università Tor Vergata, Roma, Italy
Search for more papers by this authorFranco Ajmar
Cattedra di Genetica Medica, ISMI, Università di Genova, Italy
Search for more papers by this authorMarina Frontali
Istituto di Medicina Sperimentale, CNR, Roma, Italy
Search for more papers by this authorAbstract
A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations.
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