Estimating platelet production in patients with HIV-related thrombocytopenia using the immature platelet fraction† ‡
Corresponding Author
Brian Garibaldi
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of Pulmonary and Critical Care Medicine, 1830 E. Monument Street, 5th Floor, Baltimore, MD 21287Search for more papers by this authorRupal Malani
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorHsin-Chieh Yeh
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorEvan Lipson
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorDeborah Michell
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorMosi Bennett
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorAlison Moliterno
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorMichael A. McDevitt
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorThomas S. Kickler
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorCorresponding Author
Brian Garibaldi
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of Pulmonary and Critical Care Medicine, 1830 E. Monument Street, 5th Floor, Baltimore, MD 21287Search for more papers by this authorRupal Malani
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorHsin-Chieh Yeh
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorEvan Lipson
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorDeborah Michell
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorMosi Bennett
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorAlison Moliterno
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorMichael A. McDevitt
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorThomas S. Kickler
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorConflict of Interest: Nothing to report.
Preliminary results of this work were presented in abstract form at the American Society of Hematology, December 2007.
References
- 1 Colebunders R,De Schacht C,Vanwolleghem T,Callens S. Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection. Int J Infect Dis 2004; 8: 315–316.
- 2 Hymes KB,Karpatkin S. Human immunodeficiency virus infection and thrombotic microangiopathy. Semin Hematol 1997; 34: 117–125.
- 3 Miller RF,Scully M,Cohen H, et al. Thrombotic thrombocytopaenic purpura in HIV-infected patients. Int J STD AIDS 2005; 16: 538–542.
- 4 Li Z,Nardi MA,Karpatkin S. Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia. Blood. 2005; 106: 572–576.
- 5 Ballem PJ,Belzberg A,Devine DV, et al. Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection. N Engl J Med 1992; 327: 1779–1784.
- 6 Camino N,Nunez M,Blanco F, et al. Indinavir-induced thrombocytopenia. AIDS Patient Care STDS 2003; 17: 103–104.
- 7 Scaradavou A. HIV-related thrombocytopenia. Blood Rev 2002; 16: 73–76.
- 8 Ingram M,Coopersmith A. Reticulated platelets following acute blood loss. Br J Haematol 1969; 17: 225–229.
- 9 Kienast J,Schmitz G. Flow cytometric analysis of thiazole orange uptake by platelets: A diagnostic aid in the evaluation of thrombocytopenic disorders. Blood 1990; 75: 116–121.
- 10 Rinder HM,Munz UJ,Ault KA, et al. Reticulated platelets in the evaluation of thrombopoietic disorders. Arch Pathol Lab Med 1993; 117: 606–610.
- 11 Ault KA,Rinder HM,Mitchell J, et al. The significance of platelets with increased RNA content (reticulated platelets). Am J Clin Pathol 1992; 98: 637–646.
- 12 Abe Y,Wada H,Sakakura M, et al. Usefulness of fully automated measurement of reticulated platelets using whole blood. Clin Appl Thromb Hemost 2005; 11: 263–270.
- 13 Kickler TS,Oguni S,Borowitz MJ. A clinical evaluation of high fluorescent platelet fraction percentage in thrombocytopenia. Am J Clin Pathol 2006; 125: 282–287.
- 14 Sakata T. Reagent characteristics in XE-2100 NRBC channel. Sysmex J Int 2000; 10: 41–46.
- 15 Briggs C,Kunka S,Hart D, et al. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol 2004; 126: 93–99.
- 16 Saigo K,Sakota Y,Masuda Y, et al. Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients. Transfus Apher Sci 2008; 38: 127–132.
- 17 Zucker ML,Murphy CA,Rachel JM, et al. Immature platelet fraction as a predictor of platelet recovery following hematopoietic progenitor cell transplantation. Lab Hematol 2006; 12: 125–130.
- 18 Briggs C,Hart D,Kunka S, et al. Immature platelet fraction measurement: A future guide to platelet transfusion requirement after haematopoietic stem cell transplantation. Transfus Med 2006; 16: 101–109.
- 19 Takami A,Shibayama M,Orito M, et al. Immature platelet fraction for prediction of platelet engraftment after allogeneic stem cell transplantation. Bone Marrow Transplant 2007; 39: 501–507.
- 20 Ahmad R,Iannello A,Samarani S, et al. Contribution of platelet activation to plasma IL-18 concentrations in HIV-infected AIDS patients. AIDS 2006; 20: 1907–1909.
- 21 Holme PA,Muller F,Solum NO, et al. Enhanced activation of platelets with abnormal release of RANTES in human immunodeficiency virus type 1 infection. FASEB J 1998; 12: 79–89.
- 22 Watala C,Boncler M,Gresner P. Blood platelet abnormalities and pharmacological modulation of platelet reactivity in patients with diabetes mellitus. Pharmacol Rep 2005; 57: 42–58.
- 23 Watala C. Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitus. Curr Pharm Des 2005; 11: 2331–2365.
- 24 Watala C,Boncler M,Pietrucha T,Trojanowski Z. Possible mechanisms of the altered platelet volume distribution in type 2 diabetes: Does increased platelet activation contribute to platelet size heterogeneity? Platelets 1999; 10: 52–60.
- 25 Segal JB,Moliterno AR. Platelet counts differ by sex, ethnicity, and age in the United States. Ann Epidemiol 2006; 16: 123–130.
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