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Boron Ions: Simultaneous Boron Ion-Channel/Growth Factor Receptor Activation for Enhanced Vascularization (Adv. Biosys. 1/2019)
First published: 11 January 2019
Graphical Abstract
Active NaBC1 physically co-localizes with other transmembrane proteins, such as active VEGFR, leading to simultaneous enhanced intracellular signaling in the presence of ultra-low doses of ligand (simulating physiological levels). To fully potentiate the ability of biomaterials to control vascularization mechanisms, full attention needs to be given to the interplay between specific cell membrane receptors in order to mimic biological niches at the molecular level. In article number 1800220, Patricia Rico, Manuel Salmerón-Sánchez, and co-workers present a new therapeutic strategy for vascularization using ions instead of growth factors.
