Isolierung von Bordetella-Phagen aus Bakterienstämen der Impfstoffproduktion^†

It has been demonstrated that strains of Bordetella pertussis used for vaccine production contain temperate phages. It can be conducted from many experiments performed in our laboratory. that 10–100 phages per 10¹⁰ bacteria are released. However, the production of bacterial mass is not markedly influenced by lysogeny.

Strains of Bordetella bronchiseptica used for production of vaccine against Rhinitis atrophicans of pigs have temperate phages too. These phages may cause a complete lysis during a submerse cultivation.

The phages of Bordetella pertussis and Bordetella bronchiseptica can be propagted on Bordetella parapertussis.